INT129751

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.91
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Anatomy Link Frequency
hippocampus 6
dorsal horn 2
CHO 2
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 128 100.00 Very High Very High Very High
Endep 4 99.98 Very High Very High Very High
Dorsal horn 43 99.40 Very High Very High Very High
Kinase C 5 98.40 Very High Very High Very High
Kappa opioid receptor 2 97.24 Very High Very High Very High
Spinal cord 162 94.72 High High
Opioid 2 94.52 High High
antagonist 5 94.24 High High
Pain 257 93.12 High High
tricyclic antidepressant 7 92.28 High High
Disease Link Frequency Relevance Heat
Chronic Hepatitis 31 99.24 Very High Very High Very High
Glioma 1 98.72 Very High Very High Very High
Hepatitis C Virus Infection 8 97.32 Very High Very High Very High
Hepatitis 34 95.88 Very High Very High Very High
Disease 15 94.80 High High
Fibrosis 9 94.44 High High
Pain 353 93.12 High High
Cirrhosis 57 91.36 High High
Urological Neuroanatomy 5 89.72 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the hippocampus
Regulation (Effects) of Phosphorylation (phosphorylation) of ERK1 in hippocampus associated with hippocampus
1) Confidence 0.55 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.38 Pain Relevance 0.30
In the canine samples, an up regulation of the levels of phosphorylated ERK1/2 was observed in CH and LDH.
Regulation (regulation) of Phosphorylation (phosphorylated) of ERK1 associated with chronic hepatitis
2) Confidence 0.44 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.68 Pain Relevance 0.06
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Regulation (dose-dependent) of Phosphorylation (phosphorylation) of p44
3) Confidence 0.44 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Regulation (detected) of Phosphorylation (phosphorylation) of p44
4) Confidence 0.44 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the hippocampus
Regulation (Effects) of Phosphorylation (phosphorylation) of ERK1 in hippocampus associated with hippocampus
5) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.38 Pain Relevance 0.30
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the S1 area
Regulation (Effects) of Phosphorylation (phosphorylation) of ERK1
6) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.24 Pain Relevance 0.49
Effects of s.c. injection of saline or bee venom on the phosphorylation of ERK1 and ERK2 in the hippocampus
Regulation (hippocampus) of Phosphorylation (phosphorylation) of ERK1 in hippocampus associated with hippocampus
7) Confidence 0.40 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.38 Pain Relevance 0.30
In the current study, we tested if N/OFQ and two PKC activators [phorbol 12,13-dibutyrate (PDBu) and ingenol 3,20-dibenzoate (IDB)] affected the phosphorylation level of ERK-1/2 and its nuclear substrate, ETS-like transcription factor-1 (Elk-1), using western blots.
Regulation (affected) of Phosphorylation (phosphorylation) of ERK-1 associated with kinase c
8) Confidence 0.32 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20331962 Disease Relevance 0 Pain Relevance 0.29
Amitriptyline regulated ERK1/2 phosphorylation and activity in CHO/KOR and C6 glioma cells endogenously expressing kappa-opioid receptors, and this effect was attenuated by the kappa-opioid antagonist nor-binaltorphimine.
Regulation (regulated) of Phosphorylation (phosphorylation) of ERK1 in CHO associated with antagonist, kappa opioid receptor, opioid, endep and glioma
9) Confidence 0.26 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19828880 Disease Relevance 0.19 Pain Relevance 1.23
Figure 4A shows that phosphorylation of ERK1 (p44) protein was not significantly altered in either the dorsal horn or the hippocampus at 24 h post-CFA treatment, nor after three weekly injections administered over 21 days.
Neg (nor) Regulation (altered) of Phosphorylation (phosphorylation) of p44 in dorsal horn associated with dorsal horn and hippocampus
10) Confidence 0.18 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.16 Pain Relevance 0.38
These effects appear to be rather selective as both compounds did not influence ERK1 phosphorylation (Cane 2000).


Neg (not) Regulation (influence) of Phosphorylation (phosphorylation) of ERK1
11) Confidence 0.06 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.51 Pain Relevance 0

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