INT129752

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.43
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 136 100.00 Very High Very High Very High
Dorsal horn neuron 42 100.00 Very High Very High Very High
agonist 114 99.16 Very High Very High Very High
IPN 4 98.28 Very High Very High Very High
dorsal root ganglion 71 98.24 Very High Very High Very High
nMDA receptor 37 97.92 Very High Very High Very High
nav1.8 65 96.52 Very High Very High Very High
Inflammation 49 96.48 Very High Very High Very High
central sensitization 43 95.48 Very High Very High Very High
qutenza 108 92.32 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 4 98.28 Very High Very High Very High
Ganglion Cysts 73 98.24 Very High Very High Very High
Colitis 23 96.80 Very High Very High Very High
INFLAMMATION 51 96.48 Very High Very High Very High
Hepatitis 2 75.84 Quite High
Anaplastic Astrocytoma 3 70.96 Quite High
Injury 8 62.08 Quite High
Nociception 47 61.28 Quite High
Dyspepsia 10 60.64 Quite High
Depression 2 58.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Regulation (dose-dependent) of Phosphorylation (phosphorylation) of PKC
1) Confidence 0.31 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
The dose-dependent ropivacaine-induced phosphorylation of PKC and p44/42 MAPK and the membrane translocation of Rho kinase were also detected using Western blotting.
Regulation (detected) of Phosphorylation (phosphorylation) of PKC
2) Confidence 0.31 Published 2005 Journal Anesthesiology Section Body Doc Link 16129980 Disease Relevance 0 Pain Relevance 0
In vitro PKC phosphorylation assay
Regulation (vitro) of Phosphorylation (assay) of PKC associated with kinase c
3) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.08 Pain Relevance 0.12
It is known that several protein kinases, such as PKC, PKA, PKG, MAPK and CaMKII, affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in the intracellular signal transduction pathways, and the consequences of this modulation could be central sensitization, long-lasting inhibition, and/or changes in gene expression [23-31,53,54].
Regulation (affect) of Phosphorylation (phosphorylation) of PKC in neurons associated with central sensitization and dorsal horn neuron
4) Confidence 0.23 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.54
Our previous results have revealed that both the NK-1 expression and phosphorylation of PKC?
Regulation (revealed) of Phosphorylation (phosphorylation) of PKC associated with kinase c
5) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.70 Pain Relevance 1.64
To eliminate the possible contribution of PKC phosphorylation and the activity of DAG lipase to the OAG-induced responses, we performed whole-cell recordings from HEK 293 cells transiently expressing TRPV1 with a pipette solution containing either 1 ?
Spec (possible) Regulation (contribution) of Phosphorylation (phosphorylation) of PKC associated with kinase c
6) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.08 Pain Relevance 0.51
In addition, the study indicated that ER retention signals in the alternatively spliced C-terminal domain of the NR1 subunit control release of NR1 from ER and is regulated by PKC phosphorylation [43].
Regulation (regulated) of Phosphorylation (phosphorylation) of PKC
7) Confidence 0.21 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.45 Pain Relevance 0.28
Peters et al. studied the role of phosphorylation by PKA and PKC rather than GRK2 in agonist-induced desensitization in COS-7 cells transiently expressing the 5?
Regulation (role) of Phosphorylation (phosphorylation) of PKC associated with agonist
8) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.07 Pain Relevance 0.17
Furthermore, we observed a substantial reduction in the dADP amplitude in response to PKC activation which is consistent with the report that in HEK cells, TRPC5 channels are desensitized by PKC phosphorylation of T972 located in the C-terminal region [44],[45],[46].
Regulation (desensitized) of Phosphorylation (phosphorylation) of PKC
9) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.06 Pain Relevance 0.14

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