INT12976

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Context Info
Confidence 0.50
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.16
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADRA2A) small molecule metabolic process (ADRA2A) plasma membrane (ADRA2A)
cytoplasm (ADRA2A) signal transducer activity (ADRA2A)
Anatomy Link Frequency
platelets 1
ADRA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
Clonidine 4 98.24 Very High Very High Very High
agonist 4 97.84 Very High Very High Very High
noradrenaline 3 89.04 High High
tetrodotoxin 1 84.96 Quite High
Nicotine 2 77.92 Quite High
gABA 1 68.76 Quite High
Lasting pain 4 5.00 Very Low Very Low Very Low
central sensitization 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 89.52 High High
Hypoalagesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protocol was performed under placebo and alpha-2 adrenergic (ADRA2) blockade with yohimbine in counterbalanced order to test for the influence of ADRA2 mechanisms.
Negative_regulation (blockade) of ADRA2
1) Confidence 0.50 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18713923 Disease Relevance 0.09 Pain Relevance 0
RESULTS: 1) In healthy controls, higher systolic BP was associated with lower wind-up (P < 0.05) but this was reversed in chronic pain subjects (P < 0.05); 2) higher BRS was associated with lower wind-up in healthy controls (P < 0.05) but not in the chronic pain group; 3) higher systolic BP was associated with lower BRS only in the chronic pain group (P < 0.05); and 4) ADRA2 receptor blockade did not significantly affect wind-up.
Negative_regulation (blockade) of ADRA2
2) Confidence 0.36 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18713923 Disease Relevance 0.07 Pain Relevance 0
However, alpha 2-receptor actions revealed marked species dissimilarities: clonidine caused 20-30% inhibition of human and rabbit basal adenylate cyclase, prostaglandin E1-stimulated activity and forskolin-stimulated activity, but failed to inhibit activity in the rat preparation. [3H]Rauwolscine binding indicated that rat platelets are deficient in alpha 2-receptor sites.
Negative_regulation (deficient) of alpha 2-receptor in platelets associated with clonidine
3) Confidence 0.11 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1658886 Disease Relevance 0 Pain Relevance 0.25
Likewise, alpha-2 receptor blockade did not increase cAMP production in response to epinephrine.
Negative_regulation (blockade) of alpha-2 receptor
4) Confidence 0.04 Published 1989 Journal Life Sci. Section Abstract Doc Link 2543873 Disease Relevance 0 Pain Relevance 0.23
It was not, however, blocked by methyllycaconitine, a selective antagonist of the alpha7 subtype, indicating that the action was mediated by non-alpha7 nAChRs.
Negative_regulation (antagonist) of alpha7 subtype associated with antagonist
5) Confidence 0.00 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14715938 Disease Relevance 0 Pain Relevance 0.53

General Comments

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