INT129771

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 4
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 8.92
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SMARCB1) nucleoplasm (SMARCB1) nuclear chromosome (SMARCB1)
nucleolus (SMARCB1) nucleus (SMARCB1) cell cycle (SMARCB1)
Anatomy Link Frequency
germline 2
SMARCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 2 99.16 Very High Very High Very High
metalloproteinase 12 96.40 Very High Very High Very High
headache 1 86.44 High High
Central nervous system 4 76.00 Quite High
Pain 1 63.84 Quite High
ischemia 9 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 100.00 Very High Very High Very High
Cancer 13 99.84 Very High Very High Very High
Stroke 159 99.56 Very High Very High Very High
Rhabdoid Tumor 10 99.20 Very High Very High Very High
Pain 2 99.16 Very High Very High Very High
Malignant Neoplastic Disease 4 98.60 Very High Very High Very High
Brain Injury 9 98.48 Very High Very High Very High
Neurilemmoma 2 98.48 Very High Very High Very High
Middle Cerebral Artery Infarction 75 97.92 Very High Very High Very High
Recurrence 1 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat, RT-PCR and Western blotting demonstrated no notable changes in INI1 mRNA and protein expression respectively following MCAO.
Neg (no) Regulation (changes) of INI1 associated with middle cerebral artery infarction
1) Confidence 0.58 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.67 Pain Relevance 0.03
Finally, HFN and HBMEC exposed to OGD and/or reperfusion showed no difference in mRNA and protein levels for INI1 when compared with untreated cells.


Neg (no) Regulation (difference) of INI1
2) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.53 Pain Relevance 0.05
However, in the animal model study, INI1 levels remained unchanged following stroke.
Neg (unchanged) Regulation (unchanged) of INI1 associated with stroke
3) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 1.39 Pain Relevance 0
Nuclear immunoreactivity for INI1 indicated that the tumor had no INI1 abnormalities, suggesting a secondary rhabdoid tumor.
Neg (no) Regulation (abnormalities) of INI1 associated with congenital anomalies, cancer and rhabdoid tumor
4) Confidence 0.27 Published 2006 Journal Pathol. Res. Pract. Section Abstract Doc Link 16310972 Disease Relevance 1.24 Pain Relevance 0.06
Recently, germline alterations in the SMARCB1/INI1 gene have been implicated in both familial and sporadic forms of this disorder.
Regulation (alterations) of INI1 in germline
5) Confidence 0.26 Published 2009 Journal Rev Neurol Dis Section Abstract Doc Link 19898272 Disease Relevance 1.75 Pain Relevance 0.10
Recently, germline alterations in the SMARCB1/INI1 gene have been implicated in both familial and sporadic forms of this disorder.
Regulation (alterations) of SMARCB1 in germline
6) Confidence 0.26 Published 2009 Journal Rev Neurol Dis Section Abstract Doc Link 19898272 Disease Relevance 1.75 Pain Relevance 0.10
FISH studies were negative for the INI-1 genetic mutations and chromosome 22q deletion associated with childhood atypical rhabdoid/rhabdoid tumor in 75% of cases.
Regulation (negative) of INI-1 associated with rhabdoid tumor
7) Confidence 0.08 Published 2005 Journal J. Neurooncol. Section Abstract Doc Link 16132523 Disease Relevance 1.59 Pain Relevance 0.23

General Comments

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