INT129783
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Expression of CD117, c-kit and the stem cell factor (SCF) receptor | |||||||||||||||
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Expression of CD117, c-kit and the stem cell factor (SCF) receptor | |||||||||||||||
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This case suggests that the overexpression of CD117, p53 protein, cyclin D1, and HER2/neu might be involved in the progression from lower-grade ACC to solid-type ACC and HGA. | |||||||||||||||
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They found all five tumors to be positive for CD117 and CD34 staining, while all were negative for smooth-muscle cell markers. | |||||||||||||||
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We conclude that CD117 overexpression detectable by immunohistochemistry does not play a significant role in gastric carcinoma pathways and development, although overexpression at the gene level and/or mutated CD117 expression might exist. | |||||||||||||||
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In vitro, the transfer of the c-kit gene into a breast cancer cell line resulted in the suppression of cellular growth [37]. | |||||||||||||||
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We conclude that CD117 overexpression detectable by immunohistochemistry does not play a significant role in gastric carcinoma pathways and development, although overexpression at the gene level and/or mutated CD117 expression might exist. | |||||||||||||||
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Over-expression of CD117 is almost always seen in GIST [42]. | |||||||||||||||
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Over-expression of CD117 is almost always seen in GIST [42]. | |||||||||||||||
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The tumor invaded into the submucosa, showed no signs of necrosis and had positive expression of c-kit (figure 2), focally positive expression of SMA, and negative expression of CD34. | |||||||||||||||
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We determined c-KIT with Dako CD 117 antibody in 5 cases of advanced ocular melanoma (OM) and we found positive immuno-reactivity for CD 117 in three patients. | |||||||||||||||
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However, it is now evident that this agent has more than one target, including c-kit and PDGFR, which have been shown to be overexpressed in a subset of breast cancers and associated with poor prognosis [59]. | |||||||||||||||
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Patients with a high c-kit expression had a lower response. | |||||||||||||||
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MCF 7 cells are positive for c-kit and PDGFR ? | |||||||||||||||
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Using the same experimental design as above, we transfected PBT with specific Gal-4 antisense to investigate the role of endogenous Gal-4. | |||||||||||||||
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This was shown by Moses et al. [14] to coincide with increased expression of c-Kit, another target of Gleevec. | |||||||||||||||
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Sporadic ACC tumors often overexpress c-Kit, keratin, S-100 protein, and actin [8]. | |||||||||||||||
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General Comments
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