INT129783

Context Info Confidence 0.50 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 16 Total Number 17 Disease Relevance 18.12 Pain Relevance 0.58

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT) nucleus (KIT) cytoplasm (KIT)

Anatomy Link Frequency stem cell 4 MCF 7 2 muscle cell 2 KIT (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 37 88.32 palliative 2 86.40 nud 2 82.24 headache 2 79.96 Pain 10 79.56 Inflammation 37 50.00 COX2 1 35.60 antagonist 1 34.88 COX-2 inhibitor 2 18.00 abdominal pain 4 17.36

Disease Link Frequency Relevance Heat Cancer 421 99.86 Necrosis 18 99.82 Lung Cancer 13 99.76 Adenoid Cystic Carcinoma 56 99.72 Breast Cancer 131 99.48 Stomach Cancer 294 99.28 Gastrointestinal Stromal Tumor 125 98.96 Adenocarcinoma 24 98.00 Skin Cancer 6 97.72 Sarcoma 20 97.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of CD117, c-kit and the stem cell factor (SCF) receptor

Positive_regulation (-) of Gene_expression (Expression) of kit in stem cell

1) Confidence 0.50 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0

Expression of CD117, c-kit and the stem cell factor (SCF) receptor

Positive_regulation (-) of Gene_expression (Expression) of CD117 in stem cell

2) Confidence 0.50 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0

This case suggests that the overexpression of CD117, p53 protein, cyclin D1, and HER2/neu might be involved in the progression from lower-grade ACC to solid-type ACC and HGA.

Positive_regulation (overexpression) of Gene_expression (overexpression) of CD117 associated with adenocarcinoma and adenoid cystic carcinoma

3) Confidence 0.49 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16133359 Disease Relevance 2.32 Pain Relevance 0.07

They found all five tumors to be positive for CD117 and CD34 staining, while all were negative for smooth-muscle cell markers.

Positive_regulation (positive) of Gene_expression (staining) of CD117 in muscle cell associated with cancer

4) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2409333 Disease Relevance 0.71 Pain Relevance 0

We conclude that CD117 overexpression detectable by immunohistochemistry does not play a significant role in gastric carcinoma pathways and development, although overexpression at the gene level and/or mutated CD117 expression might exist.

Positive_regulation (overexpression) of Gene_expression (overexpression) of CD117 associated with stomach cancer

5) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Abstract Doc Link PMC1475889 Disease Relevance 0.88 Pain Relevance 0

In vitro, the transfer of the c-kit gene into a breast cancer cell line resulted in the suppression of cellular growth [37].

Positive_regulation (transfer) of Gene_expression (transfer) of kit associated with breast cancer

6) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.70 Pain Relevance 0.03

We conclude that CD117 overexpression detectable by immunohistochemistry does not play a significant role in gastric carcinoma pathways and development, although overexpression at the gene level and/or mutated CD117 expression might exist.

Positive_regulation (overexpression) of Gene_expression (expression) of CD117 associated with stomach cancer

7) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Abstract Doc Link PMC1475889 Disease Relevance 0.78 Pain Relevance 0

Over-expression of CD117 is almost always seen in GIST [42].

Positive_regulation (Over) of Gene_expression (expression) of CD117 associated with gastrointestinal stromal tumor

8) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.66 Pain Relevance 0

Over-expression of CD117 is almost always seen in GIST [42].

Positive_regulation (expression) of Gene_expression (expression) of CD117 associated with gastrointestinal stromal tumor

9) Confidence 0.46 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.66 Pain Relevance 0

The tumor invaded into the submucosa, showed no signs of necrosis and had positive expression of c-kit (figure 2), focally positive expression of SMA, and negative expression of CD34.

Positive_regulation (positive) of Gene_expression (expression) of c-kit associated with necrosis and cancer

10) Confidence 0.42 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2965163 Disease Relevance 0.93 Pain Relevance 0

We determined c-KIT with Dako CD 117 antibody in 5 cases of advanced ocular melanoma (OM) and we found positive immuno-reactivity for CD 117 in three patients.

Spec (determined) Positive_regulation (determined) of Spec (determined) Gene_expression (determined) of c-KIT associated with skin cancer

11) Confidence 0.40 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 16767900 Disease Relevance 1.64 Pain Relevance 0.09

However, it is now evident that this agent has more than one target, including c-kit and PDGFR, which have been shown to be overexpressed in a subset of breast cancers and associated with poor prognosis [59].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of c-kit associated with breast cancer

12) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.75 Pain Relevance 0.04

Patients with a high c-kit expression had a lower response.

Positive_regulation (high) of Gene_expression (expression) of c-kit

13) Confidence 0.10 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.94 Pain Relevance 0.16

MCF 7 cells are positive for c-kit and PDGFR ?

Positive_regulation (for) of Gene_expression (positive) of c-kit in MCF 7

14) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.09 Pain Relevance 0

Using the same experimental design as above, we transfected PBT with specific Gal-4 antisense to investigate the role of endogenous Gal-4.

Positive_regulation (transfected) of Gene_expression (transfected) of PBT

15) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.20

This was shown by Moses et al. [14] to coincide with increased expression of c-Kit, another target of Gleevec.

Positive_regulation (increased) of Gene_expression (expression) of c-Kit

16) Confidence 0.07 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 1.10 Pain Relevance 0

Sporadic ACC tumors often overexpress c-Kit, keratin, S-100 protein, and actin [8].

Positive_regulation (overexpress) of Gene_expression (overexpress) of c-Kit associated with cancer and adenoid cystic carcinoma

17) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698276 Disease Relevance 0.84 Pain Relevance 0

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