INT129797

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
platelets 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 5 92.92 High High
agonist 6 87.76 High High
Potency 2 84.04 Quite High
Pain 8 78.40 Quite High
Serotonin 1 56.24 Quite High
imagery 3 30.68 Quite Low
withdrawal 2 9.92 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
TRP channel 7 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroleptic Malignant Syndrome 1 99.78 Very High Very High Very High
Sprains And Strains 9 76.52 Quite High
Pain 7 75.00 Quite High
Helminth Infection 14 72.44 Quite High
Loss Of Sense Of Smell 1 25.60 Quite Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Neutrophil Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The “control sponge” (K579Q, R582Q), is deficient in IP3 binding and therefore should not disrupt IP3 signalling, while the “super sponge” (R511C) has increased affinity for IP3.
Negative_regulation (deficient) of IP3 Binding (binding) of
1) Confidence 0.14 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0.22 Pain Relevance 0.03
In addition to these studies, electrotransjection of a STIM1 antibody into platelets inhibited SOCE by reducing coupling between TRPC1 and InsP3-Rs [68].
Negative_regulation (reducing) of InsP3 Binding (coupling) of in platelets
2) Confidence 0.03 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
NMS and PDBu, repressors of IP3 formation, drastically inhibited both the components of Ca2+ response. 4.
Negative_regulation (repressors) of IP3 Binding (formation) of associated with neuroleptic malignant syndrome
3) Confidence 0.00 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16133936 Disease Relevance 0.37 Pain Relevance 0.72

General Comments

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