INT12981

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.76
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort)
Anatomy Link Frequency
shell 2
plasma 1
caudate putamen 1
Cort (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 99.76 Very High Very High Very High
Nucleus accumbens 4 98.76 Very High Very High Very High
Pain 7 98.40 Very High Very High Very High
amygdala 44 98.06 Very High Very High Very High
Glutamate 132 97.64 Very High Very High Very High
Hippocampus 5 94.52 High High
noradrenaline 3 91.04 High High
gABA 20 89.76 High High
Morphine 30 88.72 High High
Intracerebroventricular 1 88.24 High High
Disease Link Frequency Relevance Heat
Stress 250 99.06 Very High Very High Very High
Pain 8 98.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

60 90.24 High High
Nociception 2 79.20 Quite High
Urological Neuroanatomy 14 67.28 Quite High
Hypersensitivity 4 44.56 Quite Low
Anxiety Disorder 20 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to stressors can impact on the responsiveness to drugs of abuse, and glucocorticoid hormones (CORT) may interact with dopamine (DA) within the nucleus accumbens shell (NAcs) to mediate these responses.
CORT Binding (interact) of in shell associated with nucleus accumbens and dopamine
1) Confidence 0.48 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.43 Pain Relevance 0.79
Since cortistatin seems to interact with acetylcholine, we decided to explore whether cortistatin participates in the system that modulates the noxious stimulus-evoked behavior.
cortistatin Binding (interact) of
2) Confidence 0.42 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14700741 Disease Relevance 0.18 Pain Relevance 0.46
Exposure to stressors can impact on the responsiveness to drugs of abuse, and glucocorticoid hormones (CORT) may interact with dopamine (DA) within the nucleus accumbens shell (NAcs) to mediate these responses.
CORT Binding (interact) of in shell associated with nucleus accumbens and dopamine
3) Confidence 0.37 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.43 Pain Relevance 0.79
Assays for plasma adrenocorticotropic hormone (ACTH), CORT and prolactin (PRL) showed that with 50 mg/kg, all three hormones rose sharply by 1 h.
CORT Binding (Assays) of in plasma
4) Confidence 0.34 Published 1991 Journal Toxicology Section Abstract Doc Link 1658985 Disease Relevance 0 Pain Relevance 0.22
Compelling evidence has shown that rapid effects of stress on glutamate transmission and its plasticity in HPC are mediated by fast non-transcriptional action of CORT, seemingly due to the binding of CORT to membrane-located MR receptors [11], [12].
CORT Binding (binding) of associated with stress and glutamate
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.73 Pain Relevance 0.48
Moreover, although there is a close relationship between the amygdala and the ventrocaudal caudate putamen, previous studies using autoradiography have shown limited binding of CORT [49], due to minimal expression of GR with no appreciable MR in the ventrocaudal caudate putamen [50].
CORT Binding (binding) of in caudate putamen associated with amygdala
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.31
Moreover, recent work has shown that acute stress may rapidly increase the level of circulating CORT that, by binding to membrane-located MR and rapid non-transcriptional action, induces the release of glutamate in HPC [11], [12], [29].
CORT Binding (binding) of associated with stress and glutamate
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.78 Pain Relevance 0.32

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