INT12981

Context Info Confidence 0.48 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 2.76 Pain Relevance 3.37

extracellular region (Cort)

Anatomy Link Frequency shell 2 plasma 1 caudate putamen 1 Cort (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 16 99.76 Nucleus accumbens 4 98.76 Pain 7 98.40 amygdala 44 98.06 Glutamate 132 97.64 Hippocampus 5 94.52 noradrenaline 3 91.04 gABA 20 89.76 Morphine 30 88.72 Intracerebroventricular 1 88.24

Disease Link Frequency Relevance Heat Stress 250 99.06 Pain 8 98.40 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 60 90.24 Nociception 2 79.20 Urological Neuroanatomy 14 67.28 Hypersensitivity 4 44.56 Anxiety Disorder 20 5.00 Disease 9 5.00 Shock 6 5.00 INFLAMMATION 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exposure to stressors can impact on the responsiveness to drugs of abuse, and glucocorticoid hormones (CORT) may interact with dopamine (DA) within the nucleus accumbens shell (NAcs) to mediate these responses.

CORT Binding (interact) of in shell associated with nucleus accumbens and dopamine

1) Confidence 0.48 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.43 Pain Relevance 0.79

Since cortistatin seems to interact with acetylcholine, we decided to explore whether cortistatin participates in the system that modulates the noxious stimulus-evoked behavior.

cortistatin Binding (interact) of

2) Confidence 0.42 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 14700741 Disease Relevance 0.18 Pain Relevance 0.46

Exposure to stressors can impact on the responsiveness to drugs of abuse, and glucocorticoid hormones (CORT) may interact with dopamine (DA) within the nucleus accumbens shell (NAcs) to mediate these responses.

CORT Binding (interact) of in shell associated with nucleus accumbens and dopamine

3) Confidence 0.37 Published 2006 Journal Psychoneuroendocrinology Section Abstract Doc Link 16584846 Disease Relevance 0.43 Pain Relevance 0.79

Assays for plasma adrenocorticotropic hormone (ACTH), CORT and prolactin (PRL) showed that with 50 mg/kg, all three hormones rose sharply by 1 h.

CORT Binding (Assays) of in plasma

4) Confidence 0.34 Published 1991 Journal Toxicology Section Abstract Doc Link 1658985 Disease Relevance 0 Pain Relevance 0.22

Compelling evidence has shown that rapid effects of stress on glutamate transmission and its plasticity in HPC are mediated by fast non-transcriptional action of CORT, seemingly due to the binding of CORT to membrane-located MR receptors [11], [12].

CORT Binding (binding) of associated with stress and glutamate

5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.73 Pain Relevance 0.48

Moreover, although there is a close relationship between the amygdala and the ventrocaudal caudate putamen, previous studies using autoradiography have shown limited binding of CORT [49], due to minimal expression of GR with no appreciable MR in the ventrocaudal caudate putamen [50].

CORT Binding (binding) of in caudate putamen associated with amygdala

6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.31

Moreover, recent work has shown that acute stress may rapidly increase the level of circulating CORT that, by binding to membrane-located MR and rapid non-transcriptional action, induces the release of glutamate in HPC [11], [12], [29].

CORT Binding (binding) of associated with stress and glutamate

7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797327 Disease Relevance 0.78 Pain Relevance 0.32

General Comments

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