INT129829

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 8.47
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 186 100.00 Very High Very High Very High
aspirin 129 93.24 High High
corticosteroid 1 91.04 High High
Inflammation 132 89.80 High High
metalloproteinase 4 89.04 High High
cINOD 23 86.40 High High
Calcium channel 10 59.20 Quite High
Potency 18 14.68 Low Low
agonist 57 5.00 Very Low Very Low Very Low
cytokine 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 381 100.00 Very High Very High Very High
Asthma 266 100.00 Very High Very High Very High
Occupational Lung Diseases 25 99.90 Very High Very High Very High
Body Weight 45 94.88 High High
Hypersensitivity 17 93.92 High High
Obesity 42 91.12 High High
INFLAMMATION 138 89.80 High High
Alzheimer's Dementia 4 83.32 Quite High
Nicotine Addiction 10 75.28 Quite High
Disease 32 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naive rats (normal controls) and AIA controls received carboxymethylcellulose only.


Regulation (controls) of AIA associated with arthritis
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.46 Pain Relevance 0.26
In contrast, the deoxypyridinoline/creatinine urinary level remained stable in normal controls but increased significantly in AIA controls.
Regulation (controls) of AIA associated with arthritis
2) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.10 Pain Relevance 0.20
The changes over the study duration were not significantly different between the arthritic rats (AIA controls) and the normal rats, and were modified by neither 10 mg/kg/day of rosiglitazone nor 30 mg/kg/day of pioglitazone (Table 6).
Regulation (controls) of AIA associated with arthritis
3) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.00 Pain Relevance 0.21
Although it is still controversial whether leukotriene modifiers are more effective in patients with AIA compared with other types of asthma, because LT plays an important role in the pathogenesis of AIA, leukotriene modifiers are the preferred medication for the long-term control of AIA.
Regulation (control) of AIA associated with asthma
4) Confidence 0.05 Published 2005 Journal Treat Respir Med Section Abstract Doc Link 16137190 Disease Relevance 1.39 Pain Relevance 0.76
Therefore, further replications in AIA patients from other populations are required to establish whether or not these structural variations affect AIA.
Neg (not) Spec (whether) Regulation (affect) of AIA associated with asthma
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.93 Pain Relevance 0.12
When comparing LDs on 8 SNPs of CACNG6 among Korean asthmatic patients and other populations (Additional file 5, Figure S3), albeit non-asthmatic Korean population has not determined, it can be assumed that a different LD status of the asthmatics may affect AIA and/or asthma-related phenotypes at least in a Korean population.
Spec (may) Regulation (affect) of AIA associated with asthma and occupational lung diseases
6) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.96 Pain Relevance 0.06
Aim of this study is to find out whether FSIP1 polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.


Regulation (affected) of AIA associated with asthma
7) Confidence 0.01 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2896935 Disease Relevance 1.55 Pain Relevance 0.40
OBJECTIVES: Aim of this study is to find out whether FSIP1 polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.
Regulation (affected) of AIA
8) Confidence 0.00 Published 2010 Journal BMC Pulm Med Section Body Doc Link 20513247 Disease Relevance 0.09 Pain Relevance 0

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