INT129832

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.40
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
spine 2
parathyroid 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 96.84 Very High Very High Very High
rheumatoid arthritis 1 83.36 Quite High
antiepileptic Drug 1 50.00 Quite Low
carbamazepine 17 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 53 100.00 Very High Very High Very High
Hypocalcemia 8 100.00 Very High Very High Very High
Osteoporosis 135 99.96 Very High Very High Very High
Body Weight 1 99.20 Very High Very High Very High
Osteoporotic Fractures 3 98.40 Very High Very High Very High
Pain 5 96.84 Very High Very High Very High
Bone Fracture 1 96.52 Very High Very High Very High
Apoptosis 4 85.68 High High
Rheumatoid Arthritis 1 83.36 Quite High
Stomach Cancer 3 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors suggest that the low number of new fractures, during extended PTH treatment and after its cessation, confirms the effect of PTH in the prevention of osteoporotic fractures.19
Positive_regulation (confirms) of Positive_regulation (extended) of PTH associated with osteoporotic fractures
1) Confidence 0.50 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0.18 Pain Relevance 0
Additionally, all patients, after the PTH course, should be given a potent antiresorptive agent to maintain the PTH-induced increased bone mass and antifracture efficacy.
Positive_regulation (increased) of Positive_regulation (induced) of PTH
2) Confidence 0.46 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.32 Pain Relevance 0
To clinicians this seems counterintuitive, because the elevated levels of parathyroid hormone (PTH) found in hyperparathyroidism typically result in reduced BMD and increased fracture risk.
Positive_regulation (result) of Positive_regulation (elevated) of parathyroid hormone in parathyroid associated with hypercalcemia
3) Confidence 0.46 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686338 Disease Relevance 0.72 Pain Relevance 0.04
Oral administration of alendronate in addition to vitamin D3 led to remarkable improvement within 2 years, not only in clinical symptoms, such as radial bone fractures and lumbar pain, but also in parameters for osteopenia, including decreased bone mineral density of the lumbar spine (P<0.01), decreased concentrations of calcium (P<0.05), increased urine levels of deoxypyridinoline (P<0.01), increased serum levels of bone-specific alkaline phosphatase (P<0.01), increased serum levels of osteocalcin (P<0.01), and increased serum levels of intact parathyroid hormone (P<0.05), although body weight did not alter.
Positive_regulation (increased) of Positive_regulation (increased) of parathyroid hormone in spine associated with pain, body weight, bone fracture and osteoporosis
4) Confidence 0.45 Published 2005 Journal J. Gastrointest. Surg. Section Abstract Doc Link 16137591 Disease Relevance 0.97 Pain Relevance 0.10
Elevated PTH levels, either as primary abnormality or as a compensatory response to hypocalcemia, can activate osteoclastic bone resorption to maintain normocalcemia.
Positive_regulation (activate) of Positive_regulation (Elevated) of PTH associated with hypocalcemia, hypercalcemia and osteoporosis
5) Confidence 0.28 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 1.22 Pain Relevance 0

General Comments

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