INT129835

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.22
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
stem cell 4
cerebellum 2
Nes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 25 91.96 High High
Neurotransmitter 4 91.04 High High
ketamine 4 86.40 High High
anesthesia 5 86.00 High High
cerebral cortex 8 76.16 Quite High
Central nervous system 5 40.72 Quite Low
alcohol 12 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.64 Very High Very High Very High
Body Weight 3 99.38 Very High Very High Very High
Neurodegenerative Disease 63 97.56 Very High Very High Very High
Epilepsy 11 96.92 Very High Very High Very High
Disease 27 96.56 Very High Very High Very High
Anxiety Disorder 18 94.64 High High
Apoptosis 48 85.72 High High
Genomic Instability 8 46.80 Quite Low
Aging 5 27.04 Quite Low
Neurological Disease 2 9.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that experimental epilepsy or pinealectomy procedure enhanced nestin immunoreactivity, but exogenous melatonin treatment (30 microg/100 g body weight, i.p.) following pinealectomy inhibited increased nestin expression induced by melatonin deprival in vermis region of newborn rat cerebellum (P < 0.001).
Negative_regulation (inhibited) of Gene_expression (expression) of nestin in cerebellum associated with epilepsy and body weight
1) Confidence 0.57 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16137769 Disease Relevance 0.78 Pain Relevance 0.19
But, the expression of nestin decreased dramatically after induction.
Negative_regulation (decreased) of Gene_expression (expression) of nestin
2) Confidence 0.42 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0
A novel inducible transgenic strategy for the ablation of nestin precursors
Negative_regulation (ablation) of Gene_expression (precursors) of nestin associated with targeted disruption
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.63 Pain Relevance 0.05
After intrastriatal grafting, NTN-c17.2 cells differentiated and gradually downregulated nestin expression, while the grafts stably overexpressed NTN.
Negative_regulation (downregulated) of Gene_expression (expression) of nestin
4) Confidence 0.23 Published 2007 Journal Mol Neurodegener Section Abstract Doc Link PMC2082017 Disease Relevance 0.65 Pain Relevance 0.05
We hypothesized that if ethanol suppressed the expression of cell-surface stem cell markers, it would similarly suppress the expression of mRNA for nestin.
Negative_regulation (suppress) of Gene_expression (expression) of nestin in stem cell
5) Confidence 0.11 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Ethanol significantly reduced the numbers of cells expressing the stem cell markers CD117, CD133, Sca-1 and ABCG2, without decreasing nestin expression.
Negative_regulation (decreasing) of Gene_expression (expression) of nestin in stem cell
6) Confidence 0.11 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1249578 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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