INT129837

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 44
Total Number 44
Disease Relevance 8.05
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
neural 4
stem cell 4
glial cell 3
vessels 3
cerebellum 2
Nes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 328 100.00 Very High Very High Very High
Peripheral nervous system 25 99.52 Very High Very High Very High
imagery 54 96.52 Very High Very High Very High
Central nervous system 95 96.28 Very High Very High Very High
nMDA receptor 34 93.92 High High
Hippocampus 82 91.48 High High
Neurotransmitter 17 91.04 High High
ketamine 18 85.60 High High
anesthesia 43 85.20 High High
dexamethasone 90 76.08 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 95 99.40 Very High Very High Very High
Epilepsy 22 99.10 Very High Very High Very High
Body Weight 8 98.98 Very High Very High Very High
Neurodegenerative Disease 211 97.08 Very High Very High Very High
Disease 106 96.00 Very High Very High Very High
Anxiety Disorder 54 94.16 High High
Brain Tumor 5 93.40 High High
Diabetes Mellitus 558 91.52 High High
Apoptosis 196 89.48 High High
Diabetic Retinopathy 84 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To the best of our knowledge, this is the first study reporting the effects of maternal epilepsy during pregnancy in pinealectomized rats on nestin immunoexpression in the newborn rat cerebellum.
Gene_expression (immunoexpression) of nestin in cerebellum associated with epilepsy
1) Confidence 0.75 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16137769 Disease Relevance 0.58 Pain Relevance 0.10
The rtTA protein is under the control of the rat nestin intron II enhancer/promoter which is specifically expressed in neural precursors [45]–[47].
Gene_expression (expressed) of nestin in neural
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.52 Pain Relevance 0.03
The coexpression of nestin with other developmental markers, such as the incorporation of BrdU (such as that seen in the present study) strongly suggests that the cells involved are immature.
Gene_expression (coexpression) of nestin
3) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.51 Pain Relevance 0.07
The detection of cells that coexpressed BrdU and nestin or PKC-?
Gene_expression (coexpressed) of nestin
4) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.37 Pain Relevance 0
The coexpression of BrdU and nestin or BrdU and PKC-?
Gene_expression (coexpression) of nestin
5) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.11 Pain Relevance 0.08
As observed for their anatomical organization, rehydration of 6 days osmotically stimulated rats induced progressive modifications of the phenotype of SON vessels, and their expression of nestin and vimentin was reestablished to control levels after 6 days of rehydration (Fig. 5C and 5F).
Gene_expression (expression) of nestin in vessels
6) Confidence 0.75 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0.06 Pain Relevance 0
Bax mice were then crossed with regulatory mice in which the rtTA transgene was controlled by the rat nestin intron II enhancer/promoter [34] which is specifically expressed in neural precursors [35] (Figure 1B).
Gene_expression (expressed) of nestin in neural
7) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.34 Pain Relevance 0
The idea that the proliferative response detected within the SON corresponds to local angiogenesis is strongly supported by the present data demonstrating that prolonged osmotic stimulation induced 1) pronounced modifications of the anatomical organization of SON capillary vessels, with both an expansion of a capillary network throughout the increased SON volume and an increase in the network density, and 2) an increased expression by SON capillaries of nestin and vimentin, two intermediate filament proteins highly expressed by newly formed endothelial cells [19,20,22,23].
Gene_expression (expressed) of nestin in capillary
8) Confidence 0.75 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0
These cells can be identified by their ability to proliferate based on the incorporation of bromodeoxyuridine (BrdU), and by the expression of progenitor markers such as nestin, membrane receptor tyrosine kinase, also designated vascular endothelial growth factor receptor-2 (Flk-1), and paired box gene 6 (Pax6) [24-27]. p27Kip1 has recently been implicated in the molecular mechanism that controls the decision of multipotent central nervous system progenitors to withdraw from the cell cycle and to maintain the differentiated state of the postmitotic cell [28].
Gene_expression (expression) of nestin in central nervous system associated with central nervous system
9) Confidence 0.75 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.57 Pain Relevance 0.07
In control, normally hydrated rats, the SON vascularization however always remains particularly dense as compared with the surrounding regions, and the SON capillary vessels always express high levels of nestin.
Gene_expression (express) of nestin in vessels
10) Confidence 0.75 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0
It was found that experimental epilepsy or pinealectomy procedure enhanced nestin immunoreactivity, but exogenous melatonin treatment (30 microg/100 g body weight, i.p.) following pinealectomy inhibited increased nestin expression induced by melatonin deprival in vermis region of newborn rat cerebellum (P < 0.001).
Gene_expression (expression) of nestin in cerebellum associated with epilepsy and body weight
11) Confidence 0.75 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16137769 Disease Relevance 0.78 Pain Relevance 0.19
A novel inducible transgenic strategy for the ablation of nestin precursors
Gene_expression (precursors) of nestin associated with targeted disruption
12) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.62 Pain Relevance 0.05
The detection of cells that coexpressed BrdU and nestin or PKC-?
Gene_expression (coexpressed) of nestin
13) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.37 Pain Relevance 0
In addition to nestin, we also observed immunostaining for PKC-?
Gene_expression (observed) of nestin
14) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.16 Pain Relevance 0.08
In a second step we looked for the expression by SON vessels of nestin or vimentin, two intermediate filament proteins that are expressed by the endothelial cells constituting newly formed capillary vessels in the developing CNS or in brain tumors [19,20,22,23].
Gene_expression (vessels) of nestin in brain associated with brain tumor
15) Confidence 0.65 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0.09 Pain Relevance 0
But, the expression of nestin decreased dramatically after induction.
Gene_expression (expression) of nestin
16) Confidence 0.58 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0
We show that 1) a large majority of the SON proliferative cells is associated with capillary vessels, 2) this proliferative response correlates with a progressive increase in density of the capillary network within the nucleus, and 3) SON capillary vessels exhibit an increased expression of nestin and vimentin, two markers of newly formed vessels.
Gene_expression (expression) of nestin in vessels
17) Confidence 0.58 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0.04
A large number of cells expressing NTN and nestin protein were detected at 4.5 d (Fig. 1D).
Gene_expression (expressing) of nestin
18) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2082017 Disease Relevance 0.26 Pain Relevance 0
Forty eight hours after differentiation, we detected the expression of nestin which is normally expressed in genuine SC [17] and SC markers p75, S-100 and GFAP [1,18] to evaluate the nature of SC-like cells.
Gene_expression (expression) of nestin
19) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.12 Pain Relevance 0
Immunostaining showed that almost all of the SC-like cells expressed nestin (Figure 4C), GFAP (Figure 4D) and S-100 (Figure 4E), and 35 ± 5% of the SC-like cells expressed p75 (Figure 4F).


Gene_expression (expressed) of nestin
20) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257969 Disease Relevance 0.13 Pain Relevance 0

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