INT129871

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
hypothalamus 3
cerebral cortex 1
Gck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tramadol 16 98.28 Very High Very High Very High
cerebral cortex 4 97.26 Very High Very High Very High
mu opioid receptor 10 91.80 High High
narcan 4 90.96 High High
dexamethasone 2 90.56 High High
Serotonin 2 73.80 Quite High
agonist 2 73.24 Quite High
Central nervous system 2 57.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose utilization of the cerebral cortex and hypothalamus was enhanced by a 4-week-tramadol administration in 90% pancreatectomized rats, in vivo, as assessed by measurement of glucokinase expression and glycogen deposition via activating insulin signaling cascade such as neuronal cells in vitro.
Positive_regulation (activating) of Gene_expression (expression) of glucokinase in hypothalamus associated with tramadol and cerebral cortex
1) Confidence 0.28 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140165 Disease Relevance 0.08 Pain Relevance 1.10
Glucose utilization of the cerebral cortex and hypothalamus was enhanced by a 4-week-tramadol administration in 90% pancreatectomized rats, in vivo, as assessed by measurement of glucokinase expression and glycogen deposition via activating insulin signaling cascade such as neuronal cells in vitro.
Positive_regulation (activating) of in cerebral cortex Gene_expression (expression) of glucokinase in hypothalamus associated with tramadol and cerebral cortex
2) Confidence 0.09 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140165 Disease Relevance 0.08 Pain Relevance 1.10

General Comments

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