INT129882

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.62
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
synovial fluid 2
joint 2
PC-3 2
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 140 87.52 High High
Kinase C 13 80.28 Quite High
Pain 6 65.04 Quite High
antagonist 5 56.96 Quite High
agonist 9 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 22 99.10 Very High Very High Very High
Arthropathy 12 98.32 Very High Very High Very High
Reprotox - General 1 20 93.84 High High
Disease 93 89.12 High High
Osteoarthritis 140 88.16 High High
Cancer 6 85.04 High High
Metastasis 6 75.00 Quite High
Drug Induced Neurotoxicity 12 60.92 Quite High
Neurodegenerative Disease 10 60.08 Quite High
Knee Osteoarthritis 6 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if Wnts contribute to C4-2B's ability to induce mixed osteoblastic/osteolytic lesions, C4-2B cells were stably transfected with either empty vector or DKK-1 expression vector to block Wnt activity.
Positive_regulation (transfected) of Gene_expression (expression) of DKK-1 associated with osteoporosis
1) Confidence 0.69 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140917 Disease Relevance 1.34 Pain Relevance 0
Previous reports have demonstrated that increased Dkk-1 levels were correlated with the pathogenesis of joint disorders [10,26,27].
Positive_regulation (increased) of Gene_expression (levels) of Dkk-1 in joint associated with arthropathy
2) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.98 Pain Relevance 0.35
The data showed that synovial fluid Dkk-1 levels in KL grade 2 and 3 were significantly elevated compared with those of KL grade 4 (p = 0.04).
Positive_regulation (elevated) of Gene_expression (levels) of Dkk-1 in synovial fluid
3) Confidence 0.49 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.33 Pain Relevance 0.14
To determine if DKK-1 masked Wnt-mediated osteoblastic activity in osteolytic PC-3 cells, the cells were stably transfected with DKK-1 short hairpin RNA.
Positive_regulation (transfected) of Gene_expression (transfected) of DKK-1 in PC-3 associated with osteoporosis
4) Confidence 0.44 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140917 Disease Relevance 1.63 Pain Relevance 0.07
induced the expression of the secreted glycoprotein Dkk-1.
Positive_regulation (induced) of Gene_expression (expression) of glycoprotein Dkk-1
5) Confidence 0.08 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

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