INT129895

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 10.22
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HPGD) oxidoreductase activity (HPGD) nucleolus (HPGD)
nucleus (HPGD) lipid metabolic process (HPGD) cytoplasm (HPGD)
Anatomy Link Frequency
colon 3
bladder 1
HPGD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 27 99.56 Very High Very High Very High
Inflammation 38 96.82 Very High Very High Very High
COX-2 inhibitor 13 89.68 High High
antagonist 14 78.40 Quite High
metalloproteinase 3 52.96 Quite High
endometriosis 2 50.00 Quite Low
COX2 2 25.00 Low Low
chemokine 23 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 332 99.64 Very High Very High Very High
Colon Cancer 177 99.60 Very High Very High Very High
Stomach Cancer 14 99.12 Very High Very High Very High
Skin Cancer 9 98.92 Very High Very High Very High
Transitional Cell Carcinoma 4 98.12 Very High Very High Very High
INFLAMMATION 49 96.82 Very High Very High Very High
Bladder Cancer 4 96.34 Very High Very High Very High
Breast Cancer 29 94.30 High High
Reprotox - General 1 35 90.40 High High
Endometriosis 3 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitriol also up-regulated the expression of 15-hydroxyprostaglandin dehydrogenase, the enzyme initiating PG catabolism.
Gene_expression (expression) of 15-hydroxyprostaglandin dehydrogenase
1) Confidence 0.75 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140963 Disease Relevance 0.50 Pain Relevance 0.11
Yan, et al. reported that 15-PGDH expression was immunohistochemically negative in 16 of 17 colon cancer cases and in 10 of 13 gastric cancers.
Gene_expression (expression) of 15-PGDH in colon associated with colon cancer and stomach cancer
2) Confidence 0.75 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.26 Pain Relevance 0.24
decreased expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an
Gene_expression (expression) of 15-PGDH
3) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.85 Pain Relevance 0.29
In one study using Northern and Western blotting-based assay, 15-PGDH levels were lower in 85% of 23 pairs of colon carcinoma samples than in adjacent normal mucosa,24 and in another study using real time RT-PCR study in breast cancer, 15-PGDH expression was down-regulated in 64% (16 of 28) of tumors.46 In addition, one bladder cancer study found that 15-PGDH was expressed in 64% (18 of 28) of transitional cell carcinomas and in 1 of 10 squamous cell carcinomas.47 In contrast, however, Yoo, et al.29 reported that 15-PGDH was immunohistochemically expressed in 54 (90%) of 60 in gastric cancer.
Gene_expression (expressed) of 15-PGDH in bladder associated with cancer, bladder cancer, breast cancer, colon cancer, skin cancer, stomach cancer and transitional cell carcinoma
4) Confidence 0.75 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 1.50 Pain Relevance 0.03
Flurbiprofen and several other NSAIDs were found to induce 15-PGDH expression in human colon cancer HT29 cells.
Gene_expression (expression) of 15-PGDH in colon associated with colon cancer and cinod
5) Confidence 0.75 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.60 Pain Relevance 0.46
We found that calcitriol inhibits the synthesis and actions of pro-inflammatory prostaglandins (PGs) by three mechanisms: (1) inhibition of the expression of cyclooxygenase-2 (COX-2), the enzyme that synthesizes PGs, (2) induction of the expression of 15-prostaglandin dehydrogenase (15-PGDH), the enzyme that inactivates PGs, and (3) decreasing the expression of prostaglandin E and prostaglandin F PG receptors, which are the mediators of PG signaling.
Gene_expression (expression) of 15-PGDH associated with inflammation
6) Confidence 0.75 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290727 Disease Relevance 1.07 Pain Relevance 0.37
Calcitriol inhibits the prostaglandin (PG) pathway by three actions: (i) the inhibition of the expression of cyclooxygenase-2 (COX-2), the enzyme that synthesizes PGs, (ii) the induction of the expression of 15-prostaglandin dehydrogenase (15-PGDH), the enzyme that inactivates PGs and (iii) decreasing the expression of EP and FP PG receptors that are essential for PG signaling.
Gene_expression (expression) of 15-PGDH
7) Confidence 0.75 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17229571 Disease Relevance 0.69 Pain Relevance 0.14
We found that calcitriol inhibits the synthesis and actions of pro-inflammatory prostaglandins (PGs) by three mechanisms: (1) inhibition of the expression of cyclooxygenase-2 (COX-2), the enzyme that synthesizes PGs, (2) induction of the expression of 15-prostaglandin dehydrogenase (15-PGDH), the enzyme that inactivates PGs, and (3) decreasing the expression of prostaglandin E and prostaglandin F PG receptors, which are the mediators of PG signaling.
Gene_expression (expression) of 15-PGDH associated with inflammation
8) Confidence 0.65 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290727 Disease Relevance 1.07 Pain Relevance 0.37
10% of tumor cells were stained.30 Representative examples of cPLA2, COX-2, mPGES-1, 15-PGDH, and VEGF immunostained tumor tissue sections are shown in Fig. 1.


Gene_expression (examples) of 15-PGDH associated with cancer
9) Confidence 0.65 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908865 Disease Relevance 0.72 Pain Relevance 0
Expression of type IIA secretory phospholipase A(2) (sPLA(2)-IIA), cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and 5-lipoxygenase (5-LO) was quantified by real-time PCR, and these five key enzymes were localized by immunohistochemistry.
Gene_expression (Expression) of 15-PGDH
10) Confidence 0.58 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20023295 Disease Relevance 0.09 Pain Relevance 0
cPLA2, COX-2, mPGES-1, 15-PGDH, and vascular endothelial growth factor (VEGF) expressions were immunohistochemically examined in 89 CRC, and their expressions were compared with each other or clinicopathologic parameters as well as VEGF as tumor progression parameters.


Spec (examined) Gene_expression (expressions) of 15-PGDH associated with cancer and colon cancer
11) Confidence 0.58 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2908865 Disease Relevance 0.70 Pain Relevance 0
Indomethacin reduced PGE2 content in normal and tumor tissue with subsequently decreased IP, HPGD and PPARgamma receptor expression in both tumor and normal colon tissue, while subtype EP1-4 receptors were not significantly influenced by indomethacin treatment.
Gene_expression (expression) of HPGD in colon associated with cancer
12) Confidence 0.23 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043083 Disease Relevance 1.17 Pain Relevance 0.20

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