INT129901

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 60
Total Number 61
Disease Relevance 22.44
Pain Relevance 6.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
liver 6
intestine 4
colon 3
brain 3
gut 3
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 2161 100.00 Very High Very High Very High
agonist 495 100.00 Very High Very High Very High
Paracetamol 14 100.00 Very High Very High Very High
Inflammation 980 99.88 Very High Very High Very High
Versed 55 99.16 Very High Very High Very High
dexamethasone 110 96.68 Very High Very High Very High
Central nervous system 18 91.56 High High
antagonist 385 90.40 High High
anesthesia 8 85.32 High High
methadone 15 83.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 947 100.00 Very High Very High Very High
Osteogenic Sarcomas 275 100.00 Very High Very High Very High
Hepatotoxicity 118 100.00 Very High Very High Very High
INFLAMMATION 703 99.88 Very High Very High Very High
Osteoporosis 385 99.88 Very High Very High Very High
Breast Cancer 440 99.80 Very High Very High Very High
Inflammatory Bowel Disease 1763 99.68 Very High Very High Very High
Disorder Of Lipid Metabolism 220 99.28 Very High Very High Very High
Endometriosis (extended) 165 99.16 Very High Very High Very High
Rickets 440 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we used a transgenic mouse expressing human PXR (hPXR) to determine the consequences of increased blood-brain barrier P-glycoprotein activity.
Gene_expression (expressing) of PXR in brain associated with targeted disruption
1) Confidence 0.73 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16837625 Disease Relevance 0.24 Pain Relevance 0.33
A similar inverse relationship between SXR and ER expression has also been shown in breast cancer cell lines [Dotzlaw et al., 1999].
Gene_expression (expression) of SXR associated with breast cancer
2) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.38 Pain Relevance 0
In addition to its high expression levels in the liver and intestine, SXR is also expressed at lower levels in the kidney and lung [Miki et al., 2005], bone [Tabb et al., 2003], and immune cells such as T cells, B cells, and mononuclear cells [Albermann et al., 2005; Owen et al., 2004; Siest et al., 2008].
Gene_expression (expression) of SXR in lung
3) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.06
This finding was paradoxical because mice expressing activated SXR have increased GST activity, and GSTs play an important role in detoxification of products from oxidative stress.
Gene_expression (expressing) of SXR associated with stress
4) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0
In both models, complete gene disruption was confirmed by the absence of SXR expression in the liver and small intestine where it is predominantly expressed; although, there are subtle phenotypic differences between the two types of mice.
Gene_expression (expression) of SXR in liver
5) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.40 Pain Relevance 0.14
In contrast, SXR overexpression causes significant decrease in cell growth inhibition and apoptosis mediated by these agents [Masuyama et al., 2007].
Gene_expression (overexpression) of SXR associated with apoptosis
6) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.66 Pain Relevance 0
They further showed, using DNA microarray analyses of nonaffected tissue from IBD patients, that expression of SXR and a known target gene, MDR1, were downregulated in the colon of ulcerative colitis patients.
Gene_expression (expression) of SXR in colon associated with inflammatory bowel disease
7) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.03 Pain Relevance 0.13
Expression of SXR has recently also been found in breast cancer tissues, but not in normal surrounding tissues of the patients [Miki et al., 2006], while other investigators find expression of SXR in both normal and cancerous breast tissue [Dotzlaw et al., 1999].
Gene_expression (expression) of SXR associated with breast cancer
8) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.39 Pain Relevance 0
Interestingly, these authors also found that there is a significant inverse correlation between SXR expression and estrogen receptor (ER) expression in endometrial tissues.
Gene_expression (expression) of SXR
9) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0
Similarly, it will be important to determine the relationship between SXR expression and breast cancer and to understand whether activating SXR promotes, or inhibits the growth of breast cancer cells.
Gene_expression (expression) of SXR associated with breast cancer
10) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.69 Pain Relevance 0
Further studies by this group showed that when SXR expression is downregulated in endometrial cancer cells, the cell growth inhibitory and apoptotic activities of anticancer agents that activate SXR, such as paclitaxel and cisplatin, are significantly enhanced.
Gene_expression (expression) of SXR associated with endometriosis (extended) and apoptosis
11) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0.05
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Gene_expression (expression) of SXR in intestine
12) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
Feeding mice with cholic acid or the synthetic FXR agonist GW4064 resulted in strong induction of SXR expression.
Gene_expression (expression) of SXR associated with agonist
13) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.35
In addition to SNPs in the protein coding region, two groups have found significant phenotypic association between polymorphisms in the promoter region (-566 and -1359, respectively) of SXR and CYP3A4 expression [King et al., 2007; Lamba et al., 2008].
Gene_expression (expression) of SXR
14) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.03
Although the downregulation of MDR1 in IBD patients may be independent of the decreased expression of SXR, these data are consistent with the possibility that dysregulation of SXR in the gut is likely to contribute to the pathophysiology of ulcerative colitis.
Gene_expression (expression) of SXR in gut associated with inflammatory bowel disease
15) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.33 Pain Relevance 0.17
Vitamin K2 bound to and activated SXR and induced expression of the SXR target genes in osteosarcoma cells.
Gene_expression (expression) of SXR associated with osteogenic sarcomas
16) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.66 Pain Relevance 0
However, this model is of questionable significance with regard to the physiological functions of CYP24 in vivo, because CYP24 is found primarily in the kidney, where SXR is expressed at very low levels.
Gene_expression (expressed) of SXR in kidney
17) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.41 Pain Relevance 0.05
Expression of SXR has recently also been found in breast cancer tissues, but not in normal surrounding tissues of the patients [Miki et al., 2006], while other investigators find expression of SXR in both normal and cancerous breast tissue [Dotzlaw et al., 1999].
Spec (investigators) Gene_expression (Expression) of SXR associated with breast cancer
18) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.38 Pain Relevance 0
Interestingly, SXR is also expressed in osteosarcoma cell lines and SXR functions as a mediator of bone homeostasis in addition to its role as a xenobiotic sensor [Tabb et al., 2003].
Gene_expression (expressed) of SXR associated with osteogenic sarcomas
19) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.29 Pain Relevance 0
A 6-bp deletion in the promoter region of NR1I2 at a putative hepatic nuclear factor binding site was suggested to have a possible influence on the promoter region and potentially inhibit SXR promoter activity and downregulate expression of SXR target genes [Lamba et al., 2008; Uno et al., 2003].
Gene_expression (expression) of SXR
20) Confidence 0.73 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.17 Pain Relevance 0.04

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