INT129902

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 6.30
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1i2) DNA binding (Nr1i2)
Anatomy Link Frequency
intestinal cells 1
CAR 1
gut 1
Nr1i2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 126 99.96 Very High Very High Very High
Paracetamol 14 99.84 Very High Very High Very High
antagonist 98 96.20 Very High Very High Very High
Bile 560 90.56 High High
Inflammation 239 83.68 Quite High
Crohn's disease 85 70.64 Quite High
Versed 14 68.76 Quite High
antidepressant 42 60.16 Quite High
depression 14 54.72 Quite High
dexamethasone 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 36 99.28 Very High Very High Very High
Inflammatory Bowel Disease 448 99.00 Very High Very High Very High
Repression 42 97.60 Very High Very High Very High
Osteoporosis 98 94.12 High High
Colitis 14 88.84 High High
Targeted Disruption 238 88.48 High High
Adverse Drug Reaction 14 86.68 High High
Lung Cancer 14 83.48 Quite High
Cancer 252 80.72 Quite High
Contusions 14 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study showed that dysregulation of the SXR gene may critically influence intestinal barrier defense and susceptibility to IBD [Langmann et al., 2004].
Regulation (dysregulation) of SXR gene associated with inflammatory bowel disease
1) Confidence 0.58 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.19 Pain Relevance 0.20
The results showed that the placement of the steroid within the ligand-binding pocket is remarkably different for SXR compared with other members of the nuclear receptor superfamily.
Regulation (different) of SXR
2) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.04
The impact of those products on SXR activities and drug metabolism has been discussed in detail in an excellent review to which the reader is referred [Staudinger et al., 2006].


Regulation (impact) of SXR
3) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.10
Interestingly, SXR can be also transcriptionally regulated by FXR [Jung et al., 2006].
Regulation (regulated) of SXR
4) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.15 Pain Relevance 0.34
Their study clearly demonstrates a protective role for SXR agonists in DSS-induced IBD and suggests that SXR-mediated repression of NF-?
Regulation (role) of SXR associated with inflammatory bowel disease, repression and agonist
5) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.29 Pain Relevance 0.25
The relatively modest differences in the response of SXR harboring non-synonymous SNPs to ligands suggest that these SNPs are probably not the sole factors mediating variations in CYP3A expression.
Regulation (response) of SXR
6) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.07
In transient transfection assays R158Q showed a marked decrease in activity on the CYP3A4 promoter, whereas R148Q had no dramatic effect on transactivation ability of SXR [Koyano et al., 2004; Lim et al., 2005].
Neg (no) Regulation (effect) of SXR
7) Confidence 0.37 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Modulation of SXR activity by many natural products has been reported.
Regulation (Modulation) of SXR
8) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.62 Pain Relevance 0.09
Although the downregulation of MDR1 in IBD patients may be independent of the decreased expression of SXR, these data are consistent with the possibility that dysregulation of SXR in the gut is likely to contribute to the pathophysiology of ulcerative colitis.
Regulation (dysregulation) of SXR in gut associated with inflammatory bowel disease
9) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 1.51 Pain Relevance 0.20
Interestingly, as a main target gene of SXR, CYP3A4 can also metabolize a wide range of endogenous compounds and xenobiotics.
Regulation (target) of SXR
10) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
The ability of tocotrienols to regulate SXR target genes in a tissue-specific manner suggests that tocotrienols are selective SXR modulators and future development of compounds that selectively activate SXR target genes in certain tissues will be possible.


Regulation (regulate) of SXR
11) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.05 Pain Relevance 0
Tocotrienols also selectively regulate the SXR target gene CYP3A4 in hepatic and intestinal cell lines, due to different expression levels of nuclear receptor corepressor NCoR in hepatic and intestinal cells [Zhou et al., 2004].
Regulation (regulate) of SXR in intestinal cells
12) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0
Numerous compounds, many of which are EDCs, can affect the activity of SXR.
Regulation (affect) of SXR
13) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.14
They found that tsukushi, matrilin-2, and CD14 antigen are primary SXR target genes and that all three genes have bone-related functions.
Regulation (target) of SXR
14) Confidence 0.25 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0
Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity.
Regulation (Role) of pregnane X receptor associated with paracetamol and hepatotoxicity
15) Confidence 0.21 Published 2005 Journal Drug Metab. Dispos. Section Title Doc Link 16141365 Disease Relevance 0.47 Pain Relevance 0.75
The cross-reactivity of lipid homeostasis and xenobiotic metabolism pathways was recently pin-pointed to converge at the transcription factor Insig-1 being regulated via both CAR and PXR [14].
Regulation (regulated) of PXR in CAR
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.12

General Comments

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