INT129903

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Context Info
Confidence 0.64
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.26
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11) nucleus (Nr1i2)
DNA binding (Nr1i2)
Nr1i2 (Mus musculus)
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 56 93.28 High High
Disease Link Frequency Relevance Heat
Hepatotoxicity 32 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters.
pregnane X receptor Regulation (regulator) of cytochrome P450 3A
1) Confidence 0.64 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 16141365 Disease Relevance 0.31 Pain Relevance 0.47
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters.
pregnane X receptor Regulation (regulator) of CYP3A
2) Confidence 0.64 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 16141365 Disease Relevance 0.31 Pain Relevance 0.48
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters.
PXR Regulation (regulator) of CYP3A
3) Confidence 0.47 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 16141365 Disease Relevance 0.31 Pain Relevance 0.48
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing enzymes, including cytochrome P450 3A (CYP3A), and transporters.
PXR Regulation (regulator) of cytochrome P450 3A
4) Confidence 0.47 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 16141365 Disease Relevance 0.31 Pain Relevance 0.47

General Comments

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