INT129906

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Inhbe)
Anatomy Link Frequency
dentate gyrus 2
Inhbe (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 35 96.28 Very High Very High Very High
addiction 1 95.20 Very High Very High Very High
Central nervous system 21 74.72 Quite High
Inflammation 75 72.88 Quite High
pain pelvic 2 72.28 Quite High
antagonist 8 66.00 Quite High
endometriosis 1 55.80 Quite High
Inflammatory response 10 45.28 Quite Low
cINOD 26 29.36 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.76 Very High Very High Very High
Neurodegenerative Disease 128 97.12 Very High Very High Very High
Cyst 3 95.12 Very High Very High Very High
Disease 8 93.92 High High
Gliosis 23 92.24 High High
Death 4 87.60 High High
Ovarian Cancer 3 78.04 Quite High
Nervous System Inflammation 1 74.08 Quite High
Reprotox - General 3 2 72.28 Quite High
Endometriosis (extended) 1 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second transgenic mouse model that causes loss of activin action (inhibin alpha-subunit transgenic mice) develops similar cystic structures, supporting a TGF-beta/activin/Smad2 dependence in the onset of this disease.
Positive_regulation (causes) of Negative_regulation (loss) of activin associated with targeted disruption, addiction and disease
1) Confidence 0.11 Published 2005 Journal Endocrinology Section Abstract Doc Link 16141389 Disease Relevance 0.92 Pain Relevance 0.20
We found that intraventricular infusion of activin A increased the number of newborn neurons in the dentate gyrus, CA3, and CA1 layers of the normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro.
Positive_regulation (increased) of Negative_regulation (infusion) of activin in dentate gyrus associated with hippocampus and gliosis
2) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.65 Pain Relevance 0.15

General Comments

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