INT129908

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.13
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 100.00 Very High Very High Very High
fibrosis 13 91.68 High High
Inflammation 33 80.72 Quite High
Osteoarthritis 91 79.96 Quite High
pain pelvic 2 66.84 Quite High
endometriosis 1 50.36 Quite High
metalloproteinase 4 14.40 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 17 99.12 Very High Very High Very High
Targeted Disruption 3 98.54 Very High Very High Very High
Cough 91 93.88 High High
Airway Remodeling 9 93.20 High High
Fibrosis 15 91.68 High High
Cancer 39 91.08 High High
Cyst 3 89.68 High High
Asthma 16 86.88 High High
Keloid Scars 4 84.72 Quite High
INFLAMMATION 34 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the increased activation of smad 2/3 observed in the bronchial tissues also indicate that TGF?
Positive_regulation (activation) of smad 2
1) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2688489 Disease Relevance 0.81 Pain Relevance 0
We speculate that this might be due to Smad2 import in the nuclei as TSA not only reduces the phosphorylation level of Smad2 but also inhibits its import to the nuclei.
Positive_regulation (level) of Smad2
2) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.17 Pain Relevance 0.04
The effects of stimulating the Smad2/3 pathway using TGF?
Positive_regulation (stimulating) of Smad2
3) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.24 Pain Relevance 0.12
Radiation induced a rapid increase in phospho-Smad-2 with an early peak at 6 hours followed by sustained phosphorylation (Figure 8a).
Positive_regulation (increase) of Smad-2
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.09 Pain Relevance 0
A second transgenic mouse model that causes loss of activin action (inhibin alpha-subunit transgenic mice) develops similar cystic structures, supporting a TGF-beta/activin/Smad2 dependence in the onset of this disease.
Positive_regulation (dependence) of Smad2 associated with targeted disruption, addiction and disease
5) Confidence 0.20 Published 2005 Journal Endocrinology Section Abstract Doc Link 16141389 Disease Relevance 0.82 Pain Relevance 0.14

General Comments

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