INT129909

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 6.24
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Inhbe)
Anatomy Link Frequency
bars 1
dentate gyrus 1
brain 1
astrocyte 1
Inhbe (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 126 99.36 Very High Very High Very High
Inflammatory response 60 98.36 Very High Very High Very High
Inflammation 450 98.12 Very High Very High Very High
Hippocampus 210 95.80 Very High Very High Very High
addiction 1 95.20 Very High Very High Very High
antagonist 48 92.84 High High
Spinal cord 6 92.32 High High
cINOD 156 82.88 Quite High
pain pelvic 2 72.00 Quite High
cytokine 84 64.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.62 Very High Very High Very High
Neurodegenerative Disease 768 99.02 Very High Very High Very High
INFLAMMATION 534 98.36 Very High Very High Very High
Cyst 3 94.84 High High
Disease 43 93.92 High High
Convulsion 12 93.00 High High
Frailty 6 92.60 High High
Gliosis 138 91.76 High High
Nervous System Inflammation 6 89.48 High High
Death 24 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second transgenic mouse model that causes loss of activin action (inhibin alpha-subunit transgenic mice) develops similar cystic structures, supporting a TGF-beta/activin/Smad2 dependence in the onset of this disease.
Negative_regulation (loss) of activin associated with targeted disruption, addiction and disease
1) Confidence 0.09 Published 2005 Journal Endocrinology Section Abstract Doc Link 16141389 Disease Relevance 0.91 Pain Relevance 0.20
These results show that inhibiting endogenous activin A is permissive for a potent underlying inflammatory response to neurodegeneration.
Negative_regulation (inhibiting) of activin associated with inflammatory response
2) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 1.03 Pain Relevance 0.38
When we added a nonsteroidal anti-inflammatory agent together with FS-288, the neurogenesis was restored to levels observed when endogenous activin A is not blocked (compare the black bars with the white bars in Fig. 7G).
Negative_regulation (blocked) of activin in bars associated with inflammation and neurodegenerative disease
3) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.91 Pain Relevance 0.56
ligands, including activin A, induce the differentiation of neural precursors into astrocytes, while also inhibiting proliferation of astrocyte lineage cells [15, 40, 46], we found no evidence for such an effect of activin A in the adult CNS in vivo.
Negative_regulation (effect) of activin in astrocyte associated with central nervous system
4) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.64 Pain Relevance 0.17
We found that intraventricular infusion of activin A increased the number of newborn neurons in the dentate gyrus, CA3, and CA1 layers of the normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro.
Negative_regulation (infusion) of activin in dentate gyrus associated with hippocampus and gliosis
5) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.65 Pain Relevance 0.15
We showed that activin A blocks LPS-mediated microglial activation in vivo and in vitro.
Negative_regulation (blocks) of activin
6) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.29 Pain Relevance 0.59
FS-288 binds to activin A and therefore blocks the activin A that is expressed in the brain from having any effect.
Negative_regulation (blocks) of activin in brain
7) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.81 Pain Relevance 0.52

General Comments

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