INT12991

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 13.39
Pain Relevance 8.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
macrophages 2
blood 2
monocyte 2
colon 2
platelets 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cOX1 14 100.00 Very High Very High Very High
COX2 13 100.00 Very High Very High Very High
cINOD 119 99.96 Very High Very High Very High
aspirin 43 99.64 Very High Very High Very High
Inflammation 33 99.40 Very High Very High Very High
Analgesic 7 99.38 Very High Very High Very High
qutenza 5 98.60 Very High Very High Very High
ischemia 10 98.04 Very High Very High Very High
Inflammatory response 4 94.44 High High
cytokine 5 93.28 High High
Disease Link Frequency Relevance Heat
Cancer 28 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
INFLAMMATION 65 99.72 Very High Very High Very High
Ocular Hypertension 2 98.92 Very High Very High Very High
Polyps 1 98.84 Very High Very High Very High
Breast Cancer 56 98.56 Very High Very High Very High
Pathologic Processes 1 98.48 Very High Very High Very High
Ulcers 3 98.40 Very High Very High Very High
Osteoid Osteoma 5 98.36 Very High Very High Very High
Nephrotoxicity 2 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together our data demonstrate that SC-560 acts at least in some cell types as an unselective COX inhibitor despite its selectivity toward COX-1 under cell-free conditions.
Negative_regulation (inhibitor) of Gene_expression (selectivity) of COX-1
1) Confidence 0.41 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816110 Disease Relevance 0 Pain Relevance 0.14
Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.
Negative_regulation (Determination) of Gene_expression (expression) of cyclooxygenase associated with inflammation, cinod and cox1
2) Confidence 0.41 Published 2004 Journal Am. J. Vet. Res. Section Title Doc Link 15198222 Disease Relevance 0.10 Pain Relevance 0.37
Adverse renal effects occur because of inhibition of the synthesis of cyclooxygenase-derived prostaglandins which act to modulate pathologic processes that would normally impair various renal functions.
Negative_regulation (inhibition) of Gene_expression (synthesis) of cyclooxygenase-derived associated with pathologic processes
3) Confidence 0.41 Published 2003 Journal J. Intern. Med. Section Abstract Doc Link 12755960 Disease Relevance 0.45 Pain Relevance 0.27
The nonsteroidal anti-inflammatory drugs (NSAIDs), one of the largest classes of pharmaceutical agents, exert most of their biologic effects by inhibiting cyclooxygenase production of prostaglandins.
Negative_regulation (inhibiting) of Gene_expression (production) of cyclooxygenase associated with inflammation and cinod
4) Confidence 0.39 Published 2003 Journal Mol Imaging Biol Section Abstract Doc Link 14630509 Disease Relevance 0.18 Pain Relevance 0.33
In human platelets, the nonsteroidal anti-inflammatory drug ibuprofen inhibited production of the cyclooxygenase product thromboxane B2 (I50 = 65 microM), whereas the lipoxygenase product 12-HETE was not appreciably affected even at 5 mM ibuprofen.
Negative_regulation (inhibited) of Gene_expression (production) of cyclooxygenase product in platelets associated with inflammation and cinod
5) Confidence 0.36 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.37 Pain Relevance 0.19
Unlike other classic NSAIDs, some fenamates given at therapeutic concentrations, have been shown to inhibit, both in vitro and in vivo, the 5-lipoxygenase pathway of arachidonic acid cascade as well as the synthesis of cyclooxygenase products.
Negative_regulation (inhibit) of Gene_expression (synthesis) of cyclooxygenase associated with cinod
6) Confidence 0.25 Published 1991 Journal Agents Actions Section Abstract Doc Link 1659152 Disease Relevance 0.09 Pain Relevance 0.15
If the new PGHS-2 selective NSAIDs can effectively inhibit inflammatory prostaglandin synthesis by PGHS-2, without inhibiting PGHS-1 prostaglandin synthesis required to regulate sodium and water resorption, and renal blood flow, it is likely that these new drugs will also have significantly less renal toxicity than present-day NSAIDs.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of PGHS-1 in blood associated with toxicity, inflammation and cinod
7) Confidence 0.23 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631045 Disease Relevance 0.51 Pain Relevance 1.11
It also suppressed the production of prostaglandin E(2) and decreased cyclooxygenase-1 expression.
Negative_regulation (decreased) of Gene_expression (expression) of cyclooxygenase-1
8) Confidence 0.21 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20627873 Disease Relevance 0.50 Pain Relevance 0.03
At 2 to 4 hours after surgery, PTGS1 expression was slightly decreased (36%, P < .001) and PTGS2 expression was markedly increased (300%, P < .001) with wide interindividual variation; at 48 hours after surgery, little detectable change in PTGS1 and PTGS2 expression was found in the control group.
Negative_regulation (decreased) of Gene_expression (expression) of PTGS1
9) Confidence 0.19 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16678543 Disease Relevance 0 Pain Relevance 0
Since the cyclooxygenases are thought to be the source of these prostaglandins, and the central target of NSAIDs, we evaluated the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in osteoid osteoma tissues from patients following surgery.
Negative_regulation (evaluated) of Gene_expression (expression) of cyclooxygenase-1 associated with cinod and osteoid osteoma
10) Confidence 0.19 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 11853083 Disease Relevance 0.98 Pain Relevance 0.45
Aspirin is well known to inhibit cyclooxygenase mediated prostaglandin synthesis.
Negative_regulation (inhibit) of Gene_expression (synthesis) of cyclooxygenase associated with aspirin
11) Confidence 0.14 Published 2006 Journal Med. Hypotheses Section Abstract Doc Link 16527427 Disease Relevance 1.73 Pain Relevance 0.39
The expression of the constitutive PG synthesis enzyme, cyclooxygenase 1, was diminished, while the level of the catabolism enzyme, 15-PG dehydrogenase, was decreased.
Negative_regulation (diminished) of Gene_expression (expression) of cyclooxygenase 1
12) Confidence 0.13 Published 2009 Journal Thyroid Section Body Doc Link 19281427 Disease Relevance 0.05 Pain Relevance 0
At present it is unclear whether nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit cyclooxygenase (COX) gene expression.
Negative_regulation (inhibit) of Gene_expression (expression) of cyclooxygenase associated with inflammation and cinod
13) Confidence 0.10 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8780708 Disease Relevance 0.17 Pain Relevance 0.32
Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis.
Negative_regulation (inhibits) of Gene_expression (synthesis) of cyclooxygenase in colon associated with apoptosis
14) Confidence 0.09 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.77 Pain Relevance 0.22
Other agents like non-steroidal anti-inflammatory drugs (NSAIDs) partly inhibit cyclooxygenase (COX) expression, as well as having a positive influence on the clinical expression of AD.
Negative_regulation (inhibit) of Gene_expression (expression) of cyclooxygenase associated with inflammation and cinod
15) Confidence 0.09 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 1.04 Pain Relevance 0.49
Gene and protein expression of cyclooxygenase-1, but not cyclooxygenase-2, were detected in intact gastric mucosa and in that exposed to ischemia/reperfusion with or without ischemic preconditioning, whereas cyclooxygenase-2 was overexpressed only in preconditioned mucosa.
Negative_regulation (detected) of Gene_expression (expression) of cyclooxygenase-1 associated with ischemia
16) Confidence 0.08 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11567657 Disease Relevance 0.29 Pain Relevance 0.37
GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation, and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta, and prostaglandin E2 in BV-2 cells.
Negative_regulation (reduced) of Gene_expression (expression) of cyclooxygenase associated with necrosis and cancer
17) Confidence 0.07 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.99 Pain Relevance 0.20
Many nonsteroidal anti-inflammatory drugs act by inhibiting the cyclooxygenase activity of prostaglandin H2 synthase (PGHS), a key enzyme in the biosynthesis of prostaglandins.
Negative_regulation (inhibiting) of Gene_expression (biosynthesis) of PGHS associated with inflammation and cinod
18) Confidence 0.07 Published 1995 Journal Chem. Biol. Section Abstract Doc Link 9383435 Disease Relevance 0.27 Pain Relevance 0.14
Rofecoxib reduced PGE2 production versus placebo from 150 min onward, while inducing analgesia through the whole observation period. mRNA assay in gingival specimens collected at tooth extraction revealed cyclooxygenase-1 expression, whereas cyclooxygenase 2 was undetectable.
Negative_regulation (revealed) of Gene_expression (expression) of cyclooxygenase-1 in tooth
19) Confidence 0.07 Published 2006 Journal Anesthesiology Section Body Doc Link 16394701 Disease Relevance 0 Pain Relevance 0
NSAIDs have the effect to inhibit synthesis of cyclooxygenase-1 (COX 1) and COX-2.
Negative_regulation (inhibit) of Gene_expression (synthesis) of cyclooxygenase-1 associated with cinod and cox1
20) Confidence 0.06 Published 2007 Journal Nippon Rinsho Section Abstract Doc Link 17926521 Disease Relevance 0.79 Pain Relevance 0.86

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