INT129920

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.64

mitochondrion (ADO) extracellular space (IFNA2) oxidoreductase activity (ADO) extracellular region (IFNA2) cell-cell signaling (IFNA2)

Anatomy Link Frequency lymphocyte 1 IFNA2 (Homo sapiens) ADO (Homo sapiens)

Pain Link Frequency Relevance Heat depression 14 98.94 Serotonin 9 98.92 Neurotransmitter 1 98.24 monoamine 3 97.90 cytokine 5 86.00 Analgesic 1 62.24 antidepressant 1 40.04 alcohol 3 25.00 addiction 2 25.00 analgesia 1 25.00

Disease Link Frequency Relevance Heat Depression 18 98.94 Hepatitis C Virus Infection 8 75.00 Stress 1 50.40 Dementia 1 33.32 Cognitive Disorder 1 29.00 Affective Disorder 3 25.00 Infection 3 25.00 Hepatitis 2 25.00 Alcohol Addiction 2 25.00 Depressive Disorder 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Second, keeping in mind that serotonin is a monoaminergic neurotransmitter classically involved in depression pathophysiology, other works have demonstrated that IFNalpha modulates the peripheral activity of indolamine-dioxygenase -- a regulating enzyme of serotonin metabolism -- possibly through lymphocyte T CD4 activation.

IFNalpha Spec (possibly) Regulation (modulates) of indolamine-dioxygenase in lymphocyte associated with neurotransmitter, depression, serotonin and monoamine

1) Confidence 0.00 Published 2005 Journal Encephale Section Abstract Doc Link 16142050 Disease Relevance 0.64 Pain Relevance 0.64

General Comments

This test has worked.