INT129920

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ADO) extracellular space (IFNA2) oxidoreductase activity (ADO)
extracellular region (IFNA2) cell-cell signaling (IFNA2)
Anatomy Link Frequency
lymphocyte 1
IFNA2 (Homo sapiens)
ADO (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 14 98.94 Very High Very High Very High
Serotonin 9 98.92 Very High Very High Very High
Neurotransmitter 1 98.24 Very High Very High Very High
monoamine 3 97.90 Very High Very High Very High
cytokine 5 86.00 High High
Analgesic 1 62.24 Quite High
antidepressant 1 40.04 Quite Low
alcohol 3 25.00 Low Low
addiction 2 25.00 Low Low
analgesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 18 98.94 Very High Very High Very High
Hepatitis C Virus Infection 8 75.00 Quite High
Stress 1 50.40 Quite High
Dementia 1 33.32 Quite Low
Cognitive Disorder 1 29.00 Quite Low
Affective Disorder 3 25.00 Low Low
Infection 3 25.00 Low Low
Hepatitis 2 25.00 Low Low
Alcohol Addiction 2 25.00 Low Low
Depressive Disorder 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, keeping in mind that serotonin is a monoaminergic neurotransmitter classically involved in depression pathophysiology, other works have demonstrated that IFNalpha modulates the peripheral activity of indolamine-dioxygenase -- a regulating enzyme of serotonin metabolism -- possibly through lymphocyte T CD4 activation.
IFNalpha Spec (possibly) Regulation (modulates) of indolamine-dioxygenase in lymphocyte associated with neurotransmitter, depression, serotonin and monoamine
1) Confidence 0.00 Published 2005 Journal Encephale Section Abstract Doc Link 16142050 Disease Relevance 0.64 Pain Relevance 0.64

General Comments

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