INT129934

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.30
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (G6PC) endoplasmic reticulum (G6PC) carbohydrate metabolic process (G6PC)
transmembrane transport (G6PC)
Anatomy Link Frequency
hepatocytes 1
stem 1
blood cells 1
G6PC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 83.92 Quite High
Inflammation 5 61.04 Quite High
Piles 2 60.08 Quite High
tricyclic antidepressant 1 58.16 Quite High
antidepressant 2 35.84 Quite Low
cocaine 5 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 10 99.84 Very High Very High Very High
Hepatocellular Cancer 1 98.86 Very High Very High Very High
Glaucoma 10 97.80 Very High Very High Very High
Repression 1 97.12 Very High Very High Very High
Cancer 12 95.20 Very High Very High Very High
Calcification 2 94.92 High High
Stress 2 94.72 High High
Bacterial Infection 2 93.72 High High
Hypoglycemia 8 91.92 High High
Hepatomegaly 6 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of our genome-wide expression data on CD34+ cells from bone marrow of normal donors (data not shown) suggest that G6PT is normally expressed in hematopoietic stem and progenitor cells.
Gene_expression (expressed) of G6PT in stem
1) Confidence 0.57 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566578 Disease Relevance 0.54 Pain Relevance 0
As accessible in 1999, a mutational analysis of peripheral blood cells showed a homozygous mutation of exon 8 of the G6PT-locus (GPTL c.1211 del CT/c.1211 del CT) confirming this diagnosis.
Gene_expression (mutation) of G6PT in blood cells
2) Confidence 0.50 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566578 Disease Relevance 1.86 Pain Relevance 0.14
The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically.
Spec (examined) Gene_expression (expression) of dThdPase
3) Confidence 0.48 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 16143032 Disease Relevance 1.12 Pain Relevance 0.08
These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
Gene_expression (production) of dThdPase associated with glaucoma and skin cancer
4) Confidence 0.48 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 16143032 Disease Relevance 1.25 Pain Relevance 0.07
The data showed that the extract acts like insulin in hepatocytes and hepatoma cells by reducing phosphoenolpyruvate carboxykinase and glucose 6-phosphatase gene expression.
Gene_expression (expression) of glucose 6-phosphatase in hepatocytes associated with hepatocellular cancer
5) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697755 Disease Relevance 0.53 Pain Relevance 0.06

General Comments

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