INT129961

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.88
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
chondrocytes 6
cartilage 2
keratinocytes 2
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 245 100.00 Very High Very High Very High
Osteoarthritis 185 98.38 Very High Very High Very High
Arthritis 46 94.92 High High
Inflammation 126 93.64 High High
rheumatoid arthritis 100 93.28 High High
agonist 3 89.88 High High
qutenza 3 89.20 High High
Hippocampus 2 84.96 Quite High
cytokine 37 76.24 Quite High
Inflammatory response 5 74.36 Quite High
Disease Link Frequency Relevance Heat
Shock 8 99.82 Very High Very High Very High
Cancer 66 99.80 Very High Very High Very High
Aggression 2 99.52 Very High Very High Very High
Osteoarthritis 188 98.38 Very High Very High Very High
INFLAMMATION 144 97.16 Very High Very High Very High
Transitional Cell Carcinoma 26 95.32 Very High Very High Very High
Arthritis 69 94.92 High High
Arthropathy 13 93.72 High High
Rheumatoid Arthritis 102 93.28 High High
Apoptosis 32 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Fluoroquinolones show contrasting effects on the expression of the two collagenases MMP-1 and MMP-13, indicating specific effects on MMP gene regulation.


Regulation (effects) of Gene_expression (expression) of MMP-1
1) Confidence 0.46 Published 2005 Journal Rheumatology (Oxford) Section Body Doc Link 16148020 Disease Relevance 0 Pain Relevance 0
The protection of matrix degradation in response to IL-1 by sierrasil may reflect a reduction in matrix metalloprotease (MMP) production (also transcriptionally regulated in response to IL-1?)
Regulation (regulated) of Gene_expression (production) of MMP
2) Confidence 0.44 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.45 Pain Relevance 0.25
They showed a correlation for MMP1 expression and tumour aggressiveness, but no detectable expression for MMP3.
Regulation (correlation) of Gene_expression (expression) of MMP1 associated with cancer and aggression
3) Confidence 0.37 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.06 Pain Relevance 0.20
METHODS: The effects of diacerein, celecoxib, diclofenac, meloxicam and indomethacin on prostaglandin (PG) E2 production, cyclo-oxygenase-2 (COX-2) protein expression, nitrite levels, presence of MMP-1 and -13, and activation of nuclear factor-kappaB (NF-kappaB) were studied on stimulated OA synoviocytes and chondrocytes.
Regulation (effects) of Gene_expression (expression) of MMP-1 in chondrocytes
4) Confidence 0.33 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18375401 Disease Relevance 0.10 Pain Relevance 0
g) was used as a positive control for caseinolytic activities and bacterial collagenase (10 ?
Regulation (control) of Gene_expression (activities) of collagenase
5) Confidence 0.29 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC404466 Disease Relevance 0 Pain Relevance 0.08
-induced expression of rabbit MMP-1 that involves binding of the RXR:PPAR?
Regulation (involves) of Gene_expression (expression) of MMP-1
6) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.35 Pain Relevance 0.17
To determine whether this inhibition extended to the level of MMP protein production and enzymatic activity, we performed Western blot analysis of MMP-1 and MMP-13 protein levels in conditioned media and an in vitro collagen destruction assay looking at the breakdown of type I collagen matrix by IL-1?
Regulation (analysis) of Gene_expression (levels) of MMP-1
7) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
With this inhibitor, no effect was found on MMP-1 production.


Neg (no) Regulation (effect) of Gene_expression (production) of MMP-1
8) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
This suggests that these inhibitors are specific for the ET-1-activated pathways since they do not affect the basal levels of MMP-1 and MMP-13.
Neg (not) Regulation (affect) of Gene_expression (levels) of MMP-1
9) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.22 Pain Relevance 0.15
Taken together, our results suggest that heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
Regulation (dependent) of Gene_expression (expression) of MMP-1 in keratinocytes associated with shock and metalloproteinase
10) Confidence 0.22 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.66 Pain Relevance 0.50
CONCLUSIONS: Fluoroquinolones show contrasting effects on the expression of the two collagenases MMP-1 and MMP-13, indicating specific effects on MMP gene regulation.


Regulation (effects) of Gene_expression (expression) of MMP-1
11) Confidence 0.20 Published 2005 Journal Rheumatology (Oxford) Section Body Doc Link 16148020 Disease Relevance 0 Pain Relevance 0
Ibuprofen produced similar effects on the expression of MMP-1 (23.4 +/- 5.0, P = .016) and MMP-3 (26.3 +/- 4.2, P = .003).
Regulation (effects) of Gene_expression (expression) of MMP-1
12) Confidence 0.19 Published 2006 Journal Clin. Pharmacol. Ther. Section Body Doc Link 16580899 Disease Relevance 0.06 Pain Relevance 0
Joe et al. examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of MMP-1 expression.
Spec (examined) Regulation (effects) of Gene_expression (expression) of MMP-1
13) Confidence 0.11 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.07 Pain Relevance 0.07
The cartilage preventive property of SPH-1 could be possible because of its down regulatory effect on the expression of MMP-1 and -13 which are thought to play a key role in the destruction of cartilage [58].
Regulation (effect) of Gene_expression (expression) of MMP-1 in cartilage
14) Confidence 0.06 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.17 Pain Relevance 0.16
Recent studies have revealed that pretreatment of human OA chondrocytes with EGCG significantly, in a dose-dependent manner, inhibited the expression and activities of MMP-1 and MMP-13 (IC50 values 27 and 16.5 ?
Regulation (values) of Gene_expression (expression) of MMP-1 in chondrocytes associated with osteoarthritis
15) Confidence 0.02 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193557 Disease Relevance 0.88 Pain Relevance 0.47
Recent studies have revealed that pretreatment of human OA chondrocytes with EGCG significantly, in a dose-dependent manner, inhibited the expression and activities of MMP-1 and MMP-13 (IC50 values 27 and 16.5 ?
Regulation (activities) of Gene_expression (expression) of MMP-1 in chondrocytes associated with osteoarthritis
16) Confidence 0.02 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193557 Disease Relevance 0.88 Pain Relevance 0.47

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