INT129987

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 63
Total Number 65
Disease Relevance 20.65
Pain Relevance 21.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
spinal 7
synapse 7
retina 3
dorsal horn 3
spinal cord 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 368 100.00 Very High Very High Very High
Dorsal horn 224 100.00 Very High Very High Very High
Anterior cingulate cortex 108 99.68 Very High Very High Very High
Kinase C 444 99.56 Very High Very High Very High
long-term potentiation 742 99.12 Very High Very High Very High
central sensitization 216 98.92 Very High Very High Very High
Glutamate 228 98.76 Very High Very High Very High
Spinal sensitization 40 98.42 Very High Very High Very High
Peripheral nerve injury 8 98.40 Very High Very High Very High
IPN 219 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 72 99.28 Very High Very High Very High
Targeted Disruption 1049 99.22 Very High Very High Very High
Nociception 669 99.16 Very High Very High Very High
Inflammatory Pain 234 98.32 Very High Very High Very High
Pain 303 97.88 Very High Very High Very High
Anxiety Disorder 881 97.76 Very High Very High Very High
Neuropathic Pain 148 97.44 Very High Very High Very High
Injury 82 96.80 Very High Very High Very High
Depression 518 95.28 Very High Very High Very High
Infection 5 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extending these findings, very recent data show that GluR1 phosphorylation also mediates the ability of norepinephrine to promote fear memory (Hu et al., 2007).
Phosphorylation (phosphorylation) of GluR1 associated with anxiety disorder
1) Confidence 0.80 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.73 Pain Relevance 0.31
To determine if GluR1 phosphorylation by CaMKII in vivo is altered in the rdta retina, the SPM proteins of the rdta retina and their littermate controls are back phosphorylated by endogenous CaMKII in the presence of Ca2+/CaM (1 mM CaCl2 and 0.02 mg/ml calmodulin).
Phosphorylation (phosphorylation) of GluR1 in retina
2) Confidence 0.72 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
-32P-ATP labeling on the film, it indicates that GluR1 has already been phosphorylated in vivo [71].
Phosphorylation (phosphorylated) of GluR1
3) Confidence 0.72 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Because CaMKII expression/activity is up-regulated in the rdta retina [34] and because GluR1 is a substrate of CaMKII [36,37,38,39,40], the increased phosphorylation of GluR1 seen here in the retinal synapses of the rdta mice could indicate a synergy between CaMKII and GluR1.
Phosphorylation (phosphorylation) of GluR1 in synapses
4) Confidence 0.72 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.14
Phosphorylation of GluR1 is increased in the synaptic membrane fraction isolated from the retinae of rdta mice
Phosphorylation (Phosphorylation) of GluR1
5) Confidence 0.72 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.04
Because GluR1 is a known substrate of CaMKII in vitro and in vivo [34,36,37,38,39,40] and because CaMKII expression/activity is up-regulated in the retinae of the rdta mice [34], GluR1 phosphorylation might also be increased in the rodless retina.
Phosphorylation (phosphorylation) of GluR1 in retina
6) Confidence 0.72 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.03
We were able to demonstrate S845 phosphorylation of GluR1 at synapses in laminae I–II of the ipsilateral dorsal horn after capsaicin injection [33].
Phosphorylation (phosphorylation) of GluR1 in synapses associated with qutenza and dorsal horn
7) Confidence 0.71 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0.09 Pain Relevance 0.59
We have previously demonstrated that acute noxious stimulation results in phosphorylation at the S845 site of GluR1 subunits at synapses in the superficial dorsal horn [33], and this is likely to lead to an increase in peak open probability of the receptors, and thus an enhancement of synaptic transmission [37].
Phosphorylation (phosphorylation) of GluR1 in dorsal horn associated with dorsal horn
8) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0.07 Pain Relevance 0.33
Zhou et al. [51] observed a rapid up-regulation of GluR1 mRNA in the lumbar dorsal horn following injection of complete Freund's adjuvant into the hindpaw, while Fang et al. [52] reported phosphorylation of this subunit at both S831 and S845 sites in Western blots of spinal cord tissue after intradermal capsaicin injection.
Phosphorylation (phosphorylation) of GluR1 in dorsal horn associated with qutenza, dorsal horn and spinal cord
9) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0.10 Pain Relevance 0.61
Western blot showed upregulated phosphorylation of GluR1 in the ACC after nerve injury.
Phosphorylation (phosphorylation) of GluR1 in ACC associated with nervous system injury and anterior cingulate cortex
10) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.86 Pain Relevance 0.74
It is postulated that CaMKII phosphorylation of GluR1 and NR2A/B may play a role in increasing the presence of these receptors within retinal synapses.
Phosphorylation (phosphorylation) of GluR1 in synapses
11) Confidence 0.62 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.05
Back phosphorylation assay for GluR1 in the rdta retina
Phosphorylation (phosphorylation) of GluR1 in retina
12) Confidence 0.62 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
These data indicate that GluR1 phosphorylation in vivo was enhanced in the rdta retinae relative to their littermate controls.
Phosphorylation (phosphorylation) of GluR1
13) Confidence 0.55 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
The GluR1 receptor subunit and its phosphorylation are simultaneously increased in retinae of the rdta mice.


Phosphorylation (phosphorylation) of GluR1
14) Confidence 0.55 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC32198 Disease Relevance 0.07 Pain Relevance 0.21
Together, these data indicate that in vivo, the amount of GluR1 and the phosphorylation of GluR1 are simultaneously enhanced in retinal synaptic fractions isolated from the retinae of rdta mice.


Phosphorylation (phosphorylation) of GluR1
15) Confidence 0.55 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Together, these data indicate that in vivo, the amount of GluR1 and the phosphorylation of GluR1 are simultaneously enhanced in retinal synaptic fractions isolated from the retinae of rdta mice.


Phosphorylation (phosphorylation) of GluR1
16) Confidence 0.55 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Phosphorylation and dephosphorylation of GluR1 play a critical role for AMPA receptor insertion and internalization [9], [12], thereby affecting AMPA receptor-mediated synaptic responses.
Phosphorylation (Phosphorylation) of GluR1
17) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.43 Pain Relevance 0.07
We therefore studied the phosphorylation of GluR1 at two main sites, Ser845 (PKA site) and Ser831 (CaMKII/PKC site) (Fig. 4F).
Phosphorylation (phosphorylation) of GluR1
18) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.49 Pain Relevance 0.10
Indeed, our biochemical results showed that phosphorylation of GluR1 is significantly decreased at PKA site (Ser845), whereas phosphorylation is unaltered at the CaMKII site (Ser831).
Phosphorylation (phosphorylation) of GluR1
19) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.79 Pain Relevance 0.14
However, phosphorylation of GluR1 at CaMKII/PKC site was not altered in neurabin KO mice (n?
Phosphorylation (phosphorylation) of GluR1 associated with targeted disruption
20) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.62 Pain Relevance 0.18

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