INT129989

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
visceral 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 99.38 Very High Very High Very High
nMDA receptor antagonist 2 99.06 Very High Very High Very High
antagonist 2 97.80 Very High Very High Very High
Spinal sensitization 4 97.52 Very High Very High Very High
IPN 9 82.00 Quite High
Hyperalgesia 4 80.48 Quite High
allodynia 5 77.72 Quite High
Dorsal horn 6 76.48 Quite High
nud 1 59.20 Quite High
Spinal cord 10 53.60 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 9 82.00 Quite High
Hyperalgesia 5 80.48 Quite High
Neuropathic Pain 9 77.72 Quite High
Pain 10 75.00 Quite High
Injury 2 68.16 Quite High
Nociception 26 60.00 Quite High
Dyspepsia 1 59.20 Quite High
INFLAMMATION 9 45.04 Quite Low
Depression 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spinal neurons, intra-thecal application of a CaMKII inhibitor, KN-93, before the painful visceral stimulus, apparently inhibits the GluR1 accumulation in the plasma membrane fraction [24].
Negative_regulation (inhibits) of Positive_regulation (accumulation) of GluR1 in visceral associated with pain
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.48 Pain Relevance 0.62
Pretreatment with a selective calcium-permeable AMPA/KA receptor antagonist (5nmol joro spider toxin), but not an NMDA receptor antagonist (25nmol d-2-amino-5-phosphonovalerate, AP-5), blocked thermal stimulus-evoked increases in phosphorylated PKA and PKC, in addition to increased cytosolic GLUR1.
Negative_regulation (blocked) of Positive_regulation (increased) of GLUR1 associated with nmda receptor antagonist and antagonist
2) Confidence 0.11 Published 2005 Journal Pain Section Abstract Doc Link 16150547 Disease Relevance 0.34 Pain Relevance 0.60

General Comments

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