INT129990

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 3.44
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
spinal 4
retina 2
nerve 2
ACC 2
synapses 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 58 100.00 Very High Very High Very High
Anterior cingulate cortex 59 99.68 Very High Very High Very High
Peripheral nerve injury 5 98.88 Very High Very High Very High
Spinal sensitization 7 97.14 Very High Very High Very High
allodynia 15 95.92 Very High Very High Very High
nMDA receptor 219 94.24 High High
Hippocampus 23 93.00 High High
amygdala 41 92.16 High High
central sensitization 9 90.28 High High
nMDA receptor antagonist 11 88.20 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 15 99.28 Very High Very High Very High
Anxiety Disorder 79 98.32 Very High Very High Very High
Injury 4 97.28 Very High Very High Very High
Neuropathic Pain 35 95.92 Very High Very High Very High
Infection 1 93.08 High High
Depression 33 84.08 Quite High
Inflammatory Pain 24 82.12 Quite High
Nociception 38 75.72 Quite High
Pain 47 75.00 Quite High
Targeted Disruption 55 71.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of GluR1 is increased in the synaptic membrane fraction isolated from the retinae of rdta mice
Positive_regulation (increased) of Phosphorylation (Phosphorylation) of GluR1
1) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.04
Because CaMKII expression/activity is up-regulated in the rdta retina [34] and because GluR1 is a substrate of CaMKII [36,37,38,39,40], the increased phosphorylation of GluR1 seen here in the retinal synapses of the rdta mice could indicate a synergy between CaMKII and GluR1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluR1 in synapses
2) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.14
Because GluR1 is a known substrate of CaMKII in vitro and in vivo [34,36,37,38,39,40] and because CaMKII expression/activity is up-regulated in the retinae of the rdta mice [34], GluR1 phosphorylation might also be increased in the rodless retina.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluR1 in retina
3) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.03
Western blot showed upregulated phosphorylation of GluR1 in the ACC after nerve injury.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of GluR1 in ACC associated with nervous system injury and anterior cingulate cortex
4) Confidence 0.59 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.86 Pain Relevance 0.75
Extending these findings, very recent data show that GluR1 phosphorylation also mediates the ability of norepinephrine to promote fear memory (Hu et al., 2007).
Positive_regulation (mediates) of Phosphorylation (phosphorylation) of GluR1 associated with anxiety disorder
5) Confidence 0.49 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.73 Pain Relevance 0.31
The GluR1 receptor subunit and its phosphorylation are simultaneously increased in retinae of the rdta mice.


Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluR1
6) Confidence 0.41 Published 2001 Journal BMC Neurosci Section Abstract Doc Link PMC32198 Disease Relevance 0.07 Pain Relevance 0.21
Together, these data indicate that in vivo, the amount of GluR1 and the phosphorylation of GluR1 are simultaneously enhanced in retinal synaptic fractions isolated from the retinae of rdta mice.


Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of GluR1
7) Confidence 0.41 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
These data indicate that GluR1 phosphorylation in vivo was enhanced in the rdta retinae relative to their littermate controls.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of GluR1
8) Confidence 0.41 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Phosphorylation of GluR1 at Ser 831 and Ser 845 sites is important for GluR1 trafficking [50].
Positive_regulation (important) of Phosphorylation (Phosphorylation) of GluR1
9) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.20 Pain Relevance 0.24
CaMKII may indirectly mediate the phosphorylation of GluR1 at the Serine845 site through adenylate cyclase and PKA, since the Ca2+-calmodulin complex can stimulate adenylate cyclase, and subsequently activate more cAMP production and PKA activity.
Positive_regulation (through) of Phosphorylation (phosphorylation) of GluR1
10) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.28 Pain Relevance 0.47
In mice with nerve ligation, the enhanced synaptic transmission was mediated by presynaptic enhancement of glutamate release probability as well as postsynaptic enhancement of AMPA receptor-mediated responses because of the phosphorylation of GluR1 subunit [7].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of GluR1 in nerve associated with glutamate
11) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2639542 Disease Relevance 0.24 Pain Relevance 0.24
We investigated whether this spinal sensitization involves activation and phosphorylation of calcium-dependent protein kinases (PKA, PKC and CaMKIIalpha), and examined if the noxious stimulus increases phosphorylated AMPA GLUR1 (pGLUR1 Ser-845 and pGLUR1 Ser-831).
Spec (examined) Positive_regulation (increases) of Phosphorylation (phosphorylated) of GLUR1 in spinal associated with spinal sensitization
12) Confidence 0.21 Published 2005 Journal Pain Section Abstract Doc Link 16150547 Disease Relevance 0.50 Pain Relevance 0.72
We investigated whether this spinal sensitization involves activation and phosphorylation of calcium-dependent protein kinases (PKA, PKC and CaMKIIalpha), and examined if the noxious stimulus increases phosphorylated AMPA GLUR1 (pGLUR1 Ser-845 and pGLUR1 Ser-831).
Spec (examined) Positive_regulation (increases) of Spec (examined) Phosphorylation (phosphorylated) of pGLUR1 in spinal associated with spinal sensitization
13) Confidence 0.15 Published 2005 Journal Pain Section Abstract Doc Link 16150547 Disease Relevance 0.50 Pain Relevance 0.72

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