INT129999

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Context Info
Confidence 0.96
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a2) extracellular region (Col1a2) proteinaceous extracellular matrix (Col1a2)
protein binding, bridging (Col1a2)
Anatomy Link Frequency
synovium 1
nociceptor 1
Col1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 99.58 Very High Very High Very High
nociceptor 1 98.60 Very High Very High Very High
Inflammatory response 1 97.44 Very High Very High Very High
cytokine 7 55.68 Quite High
Pain 7 5.00 Very Low Very Low Very Low
backache 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cramps 1 98.24 Very High Very High Very High
Urological Neuroanatomy 1 97.92 Very High Very High Very High
INFLAMMATION 2 97.24 Very High Very High Very High
Phenylketonuria 8 92.60 High High
Congenital Anomalies 1 77.12 Quite High
Cognitive Disorder 1 68.24 Quite High
Pigment Disorder 1 66.12 Quite High
Dementia 1 65.24 Quite High
Aging 2 64.96 Quite High
Metabolic Disorder 1 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four are involved in defense and inflammatory responses of neutrophils (NE, MPO, NGP, and CRAMP), three other overexpressed genes are related to extracellular matrix organization and degradation (COL1A1, COL1A2, and MMP13); the remainder were a nociceptor in sensory neurons (MrgA1), a structural gene of P lysozyme (Lzp-s), an immunoglobulin alpha heavy chain constant region gene (Igh-2), an osteocalcin-related protein precursor (Bglap-rs1), and a membrane-spanning 4 domain, subfamily A, member 3 (Ms4a3).
Protein_catabolism (degradation) of COL1A2 in nociceptor associated with cramps, inflammatory response, nociceptor and urological neuroanatomy
1) Confidence 0.96 Published 2005 Journal Mol. Genet. Metab. Section Abstract Doc Link 16150627 Disease Relevance 1.14 Pain Relevance 0.15
Although both cell types have been found to express the typical chondrogenic markers aggrecan, collagen II and Sox9 to a similar extent (Chen et al., 2006; Kim et al., 2009; Sive et al., 2002), the relative expression of collagen I, as well as biglycan, decorin and lumican, which are small leucine-rich proteoglycans that are important for collagen fibrillogenesis, is higher for mature NP cells than notochordal cells (Chen et al., 2006).
Protein_catabolism (aggrecan) of collagen II
2) Confidence 0.05 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008962 Disease Relevance 0.06 Pain Relevance 0
Previous in vitro studies have indicated that IL-11 inhibits MMP-1 and -3 protein in human synovium [79], and enhances the ability of mouse osteoblasts to synthesize MMPs responsible for the degradation of collagen I [80].
Protein_catabolism (degradation) of collagen I in synovium associated with metalloproteinase
3) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.37

General Comments

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