INT130

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Context Info
Confidence 0.43
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 4.63
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
uterine 2
Blood 1
myometrium 1
plasma 1
uterus 1
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 13 100.00 Very High Very High Very High
narcan 35 99.92 Very High Very High Very High
Dismenorea 30 99.84 Very High Very High Very High
noradrenaline 2 99.24 Very High Very High Very High
Pain 1 98.28 Very High Very High Very High
ischemia 2 97.92 Very High Very High Very High
antagonist 15 96.52 Very High Very High Very High
Endogenous opioid 4 95.56 Very High Very High Very High
cINOD 1 92.56 High High
agonist 6 84.44 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 3 99.84 Very High Very High Very High
Pre-term Labor 40 99.36 Very High Very High Very High
Pain 1 98.28 Very High Very High Very High
Cv Unclassified Under Development 2 97.92 Very High Very High Very High
Dysmenorrhea 24 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.60 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 95.76 Very High Very High Very High
INFLAMMATION 24 92.36 High High
Stress 26 90.56 High High
Bordatella Infection 2 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This permits the identification of four possible points of attack: (1) replacement of progesterone to reduce the myometrial sensitivity to oxytocin, (2) administration of beta-mimetic agents to relax the uterus and make it unresponsive to stimuli, (3) administration of ethanol to block oxytocin secretion, and (4) administration of anti-inflammatory drugs to inhibit prostaglandin synthesis.
Negative_regulation (reduce) of oxytocin in uterus associated with inflammation and cinod
1) Confidence 0.43 Published 1976 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11689 Disease Relevance 0.09 Pain Relevance 0.09
The selective oxytocin inhibitor was tested in vitro on human myometrium and decidua by the author of this article among the first in the world.
Negative_regulation (inhibitor) of oxytocin in decidua
2) Confidence 0.43 Published 2001 Journal Coll Antropol Section Abstract Doc Link 11811300 Disease Relevance 0.45 Pain Relevance 0.09
Effect of naloxone on oxytocin-induced cortisol decrease in normal men.
Negative_regulation (decrease) of oxytocin associated with narcan
3) Confidence 0.43 Published 1985 Journal Acta Endocrinol. Section Title Doc Link 2982243 Disease Relevance 0 Pain Relevance 0.70
CONCLUSIONS: Intrathecal sufentanil analgesia decreases plasma concentrations of oxytocin and cortisol in women with labor pain during the first stage of labor, but epidural bupivacaine only reduced the cortisol concentration.


Negative_regulation (decreases) of oxytocin in plasma
4) Confidence 0.43 Published 2001 Journal Reg Anesth Pain Med Section Body Doc Link 11707794 Disease Relevance 0 Pain Relevance 0
Ineffectiveness of oxytocin on intercellular communication between term pregnant human myometrial cells before labor.
Negative_regulation (Ineffectiveness) of oxytocin
5) Confidence 0.43 Published 1998 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 9579456 Disease Relevance 0 Pain Relevance 0.09
Blood samples from pregnant women and baboons not in labor were incubated in vitro with known amounts of oxytocin and TT-235.
Negative_regulation (amounts) of oxytocin in Blood
6) Confidence 0.39 Published 2002 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 12297713 Disease Relevance 0.17 Pain Relevance 0.16
The importance of oxytocin and vasopressin in mechanisms of preterm labor is confirmed by the therapeutic effect in the condition of the oxytocin and vasopressin V1a receptor blocking oxytocin analogue, atosiban.
Negative_regulation (blocking) of oxytocin associated with pre-term labor
7) Confidence 0.35 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436949 Disease Relevance 0.55 Pain Relevance 0.28
The importance of oxytocin and vasopressin in mechanisms of preterm labor is confirmed by the therapeutic effect in the condition of the oxytocin and vasopressin V1a receptor blocking oxytocin analogue, atosiban.
Negative_regulation (blocking) of oxytocin associated with pre-term labor
8) Confidence 0.35 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436949 Disease Relevance 0.55 Pain Relevance 0.28
Since naloxone abolished the inhibitory effect of oxytocin, oxytocin action on ACTH and cortisol secretion might be supposed to be mediated by an opioid pathway.
Negative_regulation (effect) of oxytocin associated with narcan and opioid
9) Confidence 0.35 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.34
Atosiban is a competitive inhibitor of the OXTR and blocks OXT-induced Ca2+ increase in myometrial cells in a reversible manner [60].
Negative_regulation (inhibitor) of OXTR
10) Confidence 0.32 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.08 Pain Relevance 0.27
Further support for a pathophysiological role of vasopressin and also of oxytocin in dysmenorrhoea is the therapeutic effect of a competitive type V1 vasopressin and oxytocin receptor antagonist in the condition.
Negative_regulation (role) of oxytocin associated with antagonist and dismenorea
11) Confidence 0.31 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7978951 Disease Relevance 0.73 Pain Relevance 0.50
Opioid-mediated inhibition of oxytocin during insulin-induced hypoglycemic stimulation of vasopressin in man.
Negative_regulation (inhibition) of oxytocin associated with opioid
12) Confidence 0.30 Published 1988 Journal Acta Endocrinol. Section Title Doc Link 2838996 Disease Relevance 0.29 Pain Relevance 0.63
When oxytocin was preceded by administration of naloxone, the ACTH and cortisol response to exercise was not reduced by oxytocin.
Negative_regulation (preceded) of oxytocin associated with narcan
13) Confidence 0.26 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.39
Since naloxone abolished the inhibitory effect of oxytocin, oxytocin action on ACTH and cortisol secretion might be supposed to be mediated by an opioid pathway.
Negative_regulation (effect) of oxytocin associated with narcan and opioid
14) Confidence 0.15 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.34
BACKGROUND: Compounds that block uterine oxytocin and vasopressin V1a receptors have a therapeutic potential in preterm labor and primary dysmenorrhoea.
Negative_regulation (block) of oxytocin in uterine associated with dismenorea and pre-term labor
15) Confidence 0.15 Published 2004 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 14678081 Disease Relevance 0.27 Pain Relevance 0.22
The selective oxytocin inhibitor was tested in vitro on human myometrium and decidua by the author of this article among the first in the world.
Negative_regulation (inhibitor) of oxytocin in myometrium
16) Confidence 0.15 Published 2001 Journal Coll Antropol Section Abstract Doc Link 11811300 Disease Relevance 0.45 Pain Relevance 0.09
The effects of PGF2 alpha were independent of extracellular Ca2+ but the effect of oxytocin was reduced with low extracellular Ca2+.
Negative_regulation (reduced) of oxytocin
17) Confidence 0.14 Published 1993 Journal J. Endocrinol. Section Abstract Doc Link 8386215 Disease Relevance 0.23 Pain Relevance 0.11
Several contributing factors have been proposed for this phenomenon in lactation, including the suckling stimulus from the pups, hormones (oxytocin and prolactin) and opioids, a decrease in the ability of noradrenaline to potentiate hypothalamic responses and changes in pituitary responsiveness to ACTH secretagogues (AVP and CRF).
Negative_regulation (decrease) of oxytocin in pituitary associated with noradrenaline and opioid
18) Confidence 0.07 Published 2005 Journal Stress Section Abstract Doc Link 16019595 Disease Relevance 0.24 Pain Relevance 0.18
Myometrial activation occurs in Phase 1 and is characterized by increased expression of myometrial contractile-associated proteins and cellular receptors for oxytocin and prostaglandins, both of which stimulate uterine contractility [12].
Negative_regulation (receptors) of oxytocin in uterine
19) Confidence 0.02 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.52 Pain Relevance 0.20

General Comments

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