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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.02
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13)
Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)
Anatomy Link Frequency
cartilage 2
joint 1
nociceptor 1
MMP13 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 64 100.00 Very High Very High Very High
Osteoarthritis 180 99.32 Very High Very High Very High
nociceptor 1 99.04 Very High Very High Very High
Inflammatory response 1 97.44 Very High Very High Very High
licofelone 45 50.00 Quite Low
Arthritis 10 26.24 Quite Low
cINOD 17 15.04 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 182 99.32 Very High Very High Very High
Cramps 1 98.24 Very High Very High Very High
Urological Neuroanatomy 1 97.92 Very High Very High Very High
INFLAMMATION 24 97.24 Very High Very High Very High
Calcification 8 95.64 Very High Very High Very High
Phenylketonuria 8 92.60 High High
Hypertrophy 4 86.84 High High
Arthritis 24 86.60 High High
Disease 25 84.56 Quite High
Arthropathy 6 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four are involved in defense and inflammatory responses of neutrophils (NE, MPO, NGP, and CRAMP), three other overexpressed genes are related to extracellular matrix organization and degradation (COL1A1, COL1A2, and MMP13); the remainder were a nociceptor in sensory neurons (MrgA1), a structural gene of P lysozyme (Lzp-s), an immunoglobulin alpha heavy chain constant region gene (Igh-2), an osteocalcin-related protein precursor (Bglap-rs1), and a membrane-spanning 4 domain, subfamily A, member 3 (Ms4a3).
Protein_catabolism (degradation) of MMP13 in nociceptor associated with cramps, inflammatory response, nociceptor and urological neuroanatomy
1) Confidence 0.36 Published 2005 Journal Mol. Genet. Metab. Section Abstract Doc Link 16150627 Disease Relevance 1.14 Pain Relevance 0.15
Furthermore, degradation of the matrix by catabolic factors such as MMP-13 make the cartilage susceptible to further mechanical erosion.
Protein_catabolism (degradation) of MMP-13 in cartilage
2) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.85 Pain Relevance 0.27
Fibrillar collagen is resistant to proteolytic degradation but at neutral pH is susceptible to degradation from the collagenases MMP-1, MMP-8 and MMP-13 that are all found within the joint.
Protein_catabolism (degradation) of MMP-13 in joint
3) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.25 Pain Relevance 0.04
Comprehensive investigation has indicated that the MMPs, including MMP-13, aggrecanase-1 (a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4), and aggrecanase-2 (ADAMTS-5), are the proteolytic enzymes that seem the most likely to be involved in the degradation of aggrecans in osteoarthritis cartilage (Lark et al 1997; Chambers et al 2001).
Protein_catabolism (degradation) of MMP-13 in cartilage associated with metalloproteinase and osteoarthritis
4) Confidence 0.07 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.77 Pain Relevance 0.49

General Comments

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