INT130014

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 5.34
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
cartilage 4
chondrocytes 1
joint 1
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 74 98.22 Very High Very High Very High
Lasting pain 2 89.48 High High
metalloproteinase 18 88.40 High High
cytokine 125 87.44 High High
Inflammation 29 79.96 Quite High
Osteoarthritis 125 52.32 Quite High
visual analogue scale 9 51.80 Quite High
Somatostatin 4 17.76 Low Low
Facet joint 76 5.00 Very Low Very Low Very Low
imagery 53 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 58 99.72 Very High Very High Very High
Fever 4 99.24 Very High Very High Very High
Tibial Fractures 15 98.60 Very High Very High Very High
Pain 75 98.22 Very High Very High Very High
Renal Insufficiency 1 97.20 Very High Very High Very High
Heart Rate Under Development 4 96.56 Very High Very High Very High
Infection 15 96.40 Very High Very High Very High
Cardiovascular Disease 2 95.88 Very High Very High Very High
Disease 21 95.12 Very High Very High Very High
Confusion 2 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could indicate that BMP-2 is upregulated as a reparative response but could also indicate that BMP-2 is merely upregulated as a pathological side effect, thereby further stimulating injury.
Positive_regulation (upregulated) of BMP-2 associated with injury
1) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.19 Pain Relevance 0
Mechanical injury was found to upregulate BMP-2 as well as BMP-2 signaling in human cartilage explants [10].
Positive_regulation (upregulate) of BMP-2 in cartilage associated with injury
2) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.18 Pain Relevance 0
Furthermore, increased concentrations of BMP-2 were measured following the cartilage regenerating operation.
Positive_regulation (increased) of BMP-2 in cartilage
3) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.09 Pain Relevance 0.09
This could indicate that BMP-2 is upregulated as a reparative response but could also indicate that BMP-2 is merely upregulated as a pathological side effect, thereby further stimulating injury.
Positive_regulation (upregulated) of BMP-2 associated with injury
4) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.19 Pain Relevance 0
When the patient received rhBMP-2 again during the third operation, he developed fever, acute oliguric renal insufficiency, symptomatic SVT with hypoxemia, confusion, and joint pain.
Positive_regulation (received) of rhBMP-2 in joint associated with pain, arthralgia, heart rate under development, renal insufficiency, fever and confusion
5) Confidence 0.50 Published 2008 Journal Journal of neurosurgery. Spine Section Abstract Doc Link 18518683 Disease Relevance 1.19 Pain Relevance 0.09
At present, more than 1,000 patients have received rhBMP-2 in clinical trials for acute open tibial fracture and interbody fusion procedures for the treatment of degenerative disc disease.
Positive_regulation (received) of rhBMP-2 associated with tibial fractures and disease
6) Confidence 0.50 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16152845 Disease Relevance 0.27 Pain Relevance 0.08
Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft?
Positive_regulation (osteoinductive) of bone morphogenetic protein-2
7) Confidence 0.49 Published 2005 Journal Acta Orthop Belg Section Title Doc Link 16152845 Disease Relevance 0.22 Pain Relevance 0.09
Mechanical injury was found to upregulate BMP-2 as well as BMP-2 signaling in human cartilage explants [10].
Positive_regulation (upregulate) of BMP-2 in cartilage associated with injury
8) Confidence 0.48 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.18 Pain Relevance 0
After all, the study does not allow explaining the BMP-2 induced reactions.
Positive_regulation (induced) of BMP-2
9) Confidence 0.48 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.14 Pain Relevance 0.14
At day 1 following surgery an average BMP-2 concentration of 185.07 ± 89.98 pg/ml (n = 28) was measured what means a statistically significant increase (p < 0.0001, power 91.3%) of BMP-2 levels after surgery.
Positive_regulation (increase) of BMP-2
10) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.32 Pain Relevance 0.13
The study does not allow drawing any conclusions how BMP-2 is acting; we even may not determine what part of the operation -arthrotomy or cartilage surgery itself-induces the increase of BMP-2 levels.
Positive_regulation (increase) of BMP-2 in cartilage
11) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.30 Pain Relevance 0.27
This potential reduction in pain may be related to an increased vascular supply that has been observed experimentally in rhBMP-2 induced bone formation.
Positive_regulation (induced) of rhBMP-2 associated with pain
12) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.97 Pain Relevance 0.19
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of BMP-2
13) Confidence 0.29 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Positive_regulation (increase) of BMP-2
14) Confidence 0.29 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.04
In addition, the in vivo injection of AdLMP-1 resulted in a significant elevation of mRNA levels of LMP-1, BMP-2, and BMP-7.
Positive_regulation (elevation) of BMP-2
15) Confidence 0.29 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.07 Pain Relevance 0.03
The mRNA levels of BMP-2 and BMP-7 were also upregulated.
Positive_regulation (upregulated) of BMP-2
16) Confidence 0.29 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.03
This is in concordance with other studies showing BMP-2 stimulated murine proteoglycan synthesis and BMP-2 induced enhancement of collagen type II expression in chondrocytes seeded in alginate [25,26].
Positive_regulation (stimulated) of BMP-2 in chondrocytes
17) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.26 Pain Relevance 0.10
Significant upregulation was seen for bone morphogenetic protein-2 inducible kinase and interleukin 17C.
Positive_regulation (upregulation) of bone morphogenetic protein-2
18) Confidence 0.17 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.21 Pain Relevance 0.08
Possible mechanisms of statins in bone formation involve stimulation of BMP-2 and endothelial nitric oxide synthase (eNOS) [13,47-50].
Positive_regulation (stimulation) of BMP-2
19) Confidence 0.12 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193734 Disease Relevance 0.32 Pain Relevance 0

General Comments

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