INT130019

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.60
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
OGE 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 18 98.80 Very High Very High Very High
Cannabinoid receptor 64 98.48 Very High Very High Very High
Osteoarthritis 178 94.20 High High
rheumatoid arthritis 198 93.92 High High
Inflammatory mediators 7 92.60 High High
Mechanotransduction 8 91.28 High High
Endocannabinoid 86 69.00 Quite High
Inflammation 103 65.96 Quite High
Inflammatory response 10 50.00 Quite Low
Angina 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 94 99.00 Very High Very High Very High
Frailty 180 94.20 High High
Rheumatoid Arthritis 198 93.92 High High
INFLAMMATION 117 92.20 High High
Apoptosis 49 78.44 Quite High
Death 26 76.80 Quite High
Injury 6 71.80 Quite High
Disease 37 66.32 Quite High
Stress 20 58.92 Quite High
Polyhydramnios 6 53.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no effect of IP on left ventricular p38 MAPK phosphorylation.
Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of p38 MAPK
1) Confidence 0.49 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
Since our results reveal no changes in the amount of ERK phosphorylation or induction of COX-2 and iNOS after pretreatment with selective concentrations of H-89 or Rp-cAMPS, it was necessary to confirm that these PKA inhibitors were being used effectively in our system.
Neg (no) Regulation (changes) of Phosphorylation (phosphorylation) of ERK
2) Confidence 0.27 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.09 Pain Relevance 0.07
M) produced a time-dependent phosphorylation of ERK1, ERK2, and p38 MAPK, indicating an increase in ERK and p38 activity which peaked at 10 minutes after stimulation (Figure 6).
Regulation (dependent) of Phosphorylation (phosphorylation) of p38
3) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.04 Pain Relevance 0.65
M) produced a time-dependent phosphorylation of ERK1, ERK2, and p38 MAPK, indicating an increase in ERK and p38 activity which peaked at 10 minutes after stimulation (Figure 6).
Regulation (dependent) of Phosphorylation (phosphorylation) of ERK2
4) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.04 Pain Relevance 0.65
To test whether stretch itself directly regulates ERK-dependent h-CaD phosphorylation, we exposed human myometrial strips to in vitro stretch.
Regulation (regulates) of Phosphorylation (phosphorylation) of ERK
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
In the current study we used an in vitro experimental stretch model to investigate the effect of stretch on ERK, CaD phosphorylation and activation of focal adhesion signaling.
Spec (investigate) Regulation (effect) of Phosphorylation (phosphorylation) of ERK associated with adhesions
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.55 Pain Relevance 0.08
Additionally, OGE pretreatment significantly upregulated Bcl-2 expression and Akt phosphorylation, and slightly affected the phosphorylation of mitogen-activated protein kinases including p38 MAPK and JNK.
Regulation (affected) of Phosphorylation (phosphorylation) of p38 MAPK in OGE
7) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952314 Disease Relevance 0.47 Pain Relevance 0.03
Additionally, the phosphorylation of p38 MAPK (p-p38) and JNK (p-JNK) was affected by neither H2O2 treatment alone nor OGE pretreatment.
Neg (nor) Regulation (affected) of Phosphorylation (phosphorylation) of p38 MAPK
8) Confidence 0.08 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.40 Pain Relevance 0

General Comments

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