INT130028

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mc4r) signal transducer activity (Mc4r)
Anatomy Link Frequency
hypothalamus 2
DRG 2
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.90 Very High Very High Very High
fluoxetine 5 99.68 Very High Very High Very High
Spinal cord 2 99.26 Very High Very High Very High
Morphine 14 98.72 Very High Very High Very High
Potency 2 95.08 Very High Very High Very High
Analgesic 2 94.76 High High
antagonist 3 93.64 High High
tolerance 8 91.72 High High
Opioid 3 91.04 High High
tail-flick 2 86.48 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 1 85.28 High High
Obesity 3 83.60 Quite High
Appetite Loss 2 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine administration increased POMC expression and reduced MC4-R expression in the hypothalamus, without changes in AgRP mRNA levels.
Positive_regulation (increased) of Gene_expression (expression) of MC4-R in hypothalamus associated with fluoxetine
1) Confidence 0.45 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359080 Disease Relevance 0.41 Pain Relevance 0.45
Using RT-PCR we demonstrated no changes in the spinal cord but there was a decrease in MOR and increase in MC4-R gene expression in the DRG of rats tolerant to morphine.
Positive_regulation (increase) of Gene_expression (expression) of MC4-R in DRG associated with opioid receptor, morphine and spinal cord
2) Confidence 0.44 Published 2005 Journal Pain Section Abstract Doc Link 16153779 Disease Relevance 0 Pain Relevance 2.25

General Comments

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