INT130036

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.47
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Emr1) plasma membrane (Emr1) signal transducer activity (Emr1)
Anatomy Link Frequency
skin 2
F4/80 2
fat 1
B cells 1
dental pulp 1
Emr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 74 93.88 High High
cytokine 64 71.04 Quite High
isoflurane 2 59.40 Quite High
anesthesia 4 58.76 Quite High
Inflammatory stimuli 8 54.80 Quite High
pulpitis 1 52.84 Quite High
Inflammatory response 18 48.08 Quite Low
agonist 14 47.12 Quite Low
antagonist 16 45.28 Quite Low
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 93.88 High High
Eosinophilia 4 89.48 High High
Rheumatoid Arthritis 20 85.40 High High
Infection 28 80.20 Quite High
Obesity 82 77.80 Quite High
Nociception 1 75.00 Quite High
Dental Fissures 1 74.80 Quite High
Pulmonary Eosinophilia 2 60.20 Quite High
Bacterial Infection 3 54.48 Quite High
Disease 28 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concurrently, CD86high cells expressing intermediate levels of CD11c and high levels of MHC class II and F4/80, assessed by using flow cytometry, increased significantly in the regional lymph nodes, suggesting migration of these cells from the dental pulp.
Gene_expression (levels) of F4/80 in dental pulp
1) Confidence 0.75 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16849394 Disease Relevance 0.23 Pain Relevance 0.05
Nevertheless, included in this set were GPCRs such as Emr1 (F4/80), C3aR, C5aR, Ccrl2 and Ccr2 that are known to be either macrophage-specific or highly expressed by macrophages [8-12], thus validating our approach.
Gene_expression (expressed) of Emr1 in F4/80
2) Confidence 0.68 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0 Pain Relevance 0
Probe detection (TaqMan® Gene Expression Master Mix, Applied Biosystems) was used for Il6 and Emr1.
Gene_expression (used) of Emr1
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.08 Pain Relevance 0.16
The mRNA expression of Emr1 in fat was increased 6.3-fold (P?
Gene_expression (expression) of Emr1 in fat
4) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.28 Pain Relevance 0.05
EMR1 that is detected by the F4/80 antibody).
Gene_expression (detected) of EMR1 in F4/80
5) Confidence 0.53 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.24 Pain Relevance 0.12
BACKGROUND: CD26 is a multifunctional cell surface glycoprotein expressed by T and B cells.
Gene_expression (expressed) of surface glycoprotein in B cells
6) Confidence 0.05 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16154213 Disease Relevance 0.07 Pain Relevance 0
It might be explained either by an immunosuppressive effect as postulated by others since retinoic acid seems to down-regulate expression of the cutaneous lymphocyte-associated antigen (CLA), a surface glycoprotein expressed by skin-homing T cells [41].
Gene_expression (expressed) of surface glycoprotein in skin
7) Confidence 0.04 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.28 Pain Relevance 0
It might be explained either by an immunosuppressive effect as postulated by others since retinoic acid seems to down-regulate expression of the cutaneous lymphocyte-associated antigen (CLA), a surface glycoprotein expressed by skin-homing T cells [41].
Gene_expression (expression) of surface glycoprotein in skin
8) Confidence 0.04 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.29 Pain Relevance 0

General Comments

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