INT130057

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.96
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
colon 1
motoneurons 1
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 98.12 Very High Very High Very High
cINOD 2 95.84 Very High Very High Very High
nMDA receptor antagonist 1 93.08 High High
tetrodotoxin 1 85.32 High High
agonist 2 85.04 High High
Osteoarthritis 64 81.80 Quite High
Spinal cord 1 80.52 Quite High
cytokine 4 58.56 Quite High
Pain 7 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 3 99.86 Very High Very High Very High
Repression 6 99.74 Very High Very High Very High
Apoptosis 37 99.48 Very High Very High Very High
Adenocarcinoma 153 98.94 Very High Very High Very High
Cancer 617 98.80 Very High Very High Very High
Skin Cancer 9 98.52 Very High Very High Very High
INFLAMMATION 13 98.12 Very High Very High Very High
Metastasis 159 97.88 Very High Very High Very High
Prostate Cancer 594 96.72 Very High Very High Very High
Targeted Disruption 15 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In further support of this hypothesis, it is notable that Cav-1 was initially identified as a gene that is specifically upregulated in metastatic versus primary cancer cells in a mouse model system.87 Gain of function studies demonstrated that ectopically overexpressed Cav-1 protects prostate cancer cells from apoptotic stimuli.90 Loss of function studies demonstrated that Cav-1 antisense cDNA converts castrate-resistant mouse prostate cancer cells to an androgen-dependent phenotype that is less prone to form metastases in vivo.91,92 As a corollary finding, selection for castrate-resistant clones in vivo is associated with increased Cav-1 levels.
Positive_regulation (increased) of Cav-1 associated with cancer, prostate cancer, apoptosis and metastasis
1) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.12 Pain Relevance 0
However, in contrast with results from motoneurons in the acute slice, NMDA-induced oscillations in culture did not depend on CaV1.3 channel activation as they still remained after nifedipine application.
Positive_regulation (activation) of CaV1 in motoneurons
2) Confidence 0.49 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16236781 Disease Relevance 0 Pain Relevance 0.17
Cav-1 is located on 7q31.1, a conserved fragile site that is frequently deleted and/or amplified in human cancers.94,95 In addition, the gene promoter for Cav-1 possesses a “CpG” island that has been reported to be hypermethylated, an event generally associated with transcriptional repression.96 However, Cav-1 expression levels do not consistently correlate with genetic and/or methylation changes of the Cav-1 gene.97 More recently, an alternative epigenetic mechanism for increased Cav-1 expression has been proposed through the aberrant, cancer-specific loss of miR-205, a noncoding microRNA that normally silences Cav-1 expression.98
Positive_regulation (located) of Cav-1 associated with cancer and repression
3) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.04 Pain Relevance 0
Cav-1 is located on 7q31.1, a conserved fragile site that is frequently deleted and/or amplified in human cancers.94,95 In addition, the gene promoter for Cav-1 possesses a “CpG” island that has been reported to be hypermethylated, an event generally associated with transcriptional repression.96 However, Cav-1 expression levels do not consistently correlate with genetic and/or methylation changes of the Cav-1 gene.97 More recently, an alternative epigenetic mechanism for increased Cav-1 expression has been proposed through the aberrant, cancer-specific loss of miR-205, a noncoding microRNA that normally silences Cav-1 expression.98
Neg (not) Positive_regulation (levels) of Cav-1 associated with cancer and repression
4) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.87 Pain Relevance 0
Cav-1 is located on 7q31.1, a conserved fragile site that is frequently deleted and/or amplified in human cancers.94,95 In addition, the gene promoter for Cav-1 possesses a “CpG” island that has been reported to be hypermethylated, an event generally associated with transcriptional repression.96 However, Cav-1 expression levels do not consistently correlate with genetic and/or methylation changes of the Cav-1 gene.97 More recently, an alternative epigenetic mechanism for increased Cav-1 expression has been proposed through the aberrant, cancer-specific loss of miR-205, a noncoding microRNA that normally silences Cav-1 expression.98
Positive_regulation (changes) of Cav-1 associated with cancer and repression
5) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.86 Pain Relevance 0
Cav-1 is located on 7q31.1, a conserved fragile site that is frequently deleted and/or amplified in human cancers.94,95 In addition, the gene promoter for Cav-1 possesses a “CpG” island that has been reported to be hypermethylated, an event generally associated with transcriptional repression.96 However, Cav-1 expression levels do not consistently correlate with genetic and/or methylation changes of the Cav-1 gene.97 More recently, an alternative epigenetic mechanism for increased Cav-1 expression has been proposed through the aberrant, cancer-specific loss of miR-205, a noncoding microRNA that normally silences Cav-1 expression.98
Positive_regulation (silences) of Cav-1 associated with cancer and repression
6) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.82 Pain Relevance 0
Previous studies demonstrated that activation of p42/p44 extracellular regulated kinase (Erk) decreased cav-1 protein levels in constitutively-active Ras transformed NIH3T3 cells [38].
Positive_regulation (activation) of cav-1 protein
7) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.16 Pain Relevance 0.03
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Positive_regulation (activation) of cav-1
8) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.21 Pain Relevance 0
Conversely, in esophageal squamous cell carcinoma, lung adenocarcinoma, prostate, colon and clear cell renal cancers, high levels of cav-1 protein is associated with increased metastatic potential[10-12].
Positive_regulation (levels) of cav-1 protein in colon associated with adenocarcinoma, renal cancer and skin cancer
9) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.43 Pain Relevance 0
In further support of this hypothesis, it is notable that Cav-1 was initially identified as a gene that is specifically upregulated in metastatic versus primary cancer cells in a mouse model system.87 Gain of function studies demonstrated that ectopically overexpressed Cav-1 protects prostate cancer cells from apoptotic stimuli.90 Loss of function studies demonstrated that Cav-1 antisense cDNA converts castrate-resistant mouse prostate cancer cells to an androgen-dependent phenotype that is less prone to form metastases in vivo.91,92 As a corollary finding, selection for castrate-resistant clones in vivo is associated with increased Cav-1 levels.
Positive_regulation (upregulated) of Cav-1 associated with cancer, prostate cancer, apoptosis and metastasis
10) Confidence 0.44 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.04 Pain Relevance 0
A positive association in the expression levels of COX-2 and caveolin-1 [35], [36] or EPH receptor A2 [37] is supported by findings of other studies employing different cell types.
Positive_regulation (association) of caveolin-1
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.90 Pain Relevance 0.32
These PPARgamma-active compounds had minimal effects on expression of cell cycle proteins and did not induce caveolin-1 in HCT-116 cells.
Neg (not) Positive_regulation (induce) of caveolin-1
12) Confidence 0.01 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16155208 Disease Relevance 0.52 Pain Relevance 0.25

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