INT130060

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (PPARG, Egr1) cytoplasm (PPARG, Egr1) nucleus (PPARG, Egr1)
nucleoplasm (PPARG) intracellular (Egr1) enzyme binding (PPARG)
PPARG (Homo sapiens)
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 87.16 High High
cINOD 2 82.84 Quite High
cytokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 2 84.40 Quite High
INFLAMMATION 2 82.64 Quite High
Colon Cancer 3 75.00 Quite High
Cancer 1 74.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data, coupled with deletion and mutation analysis of both the Egr-1 and NAG-1 gene promoters, indicate that activation of NAG-1 by these compounds was dependent on prior induction of Egr-1, and induction of these responses was PPARgamma-independent.
PPARgamma Neg (independent) Positive_regulation (independent) of Positive_regulation (induction) of Egr-1
1) Confidence 0.22 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16155208 Disease Relevance 0.46 Pain Relevance 0.24

General Comments

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