INT130080

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 2.08
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
hepatocyte 1
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 26 98.48 Very High Very High Very High
Bile 16 96.84 Very High Very High Very High
cytokine 13 95.76 Very High Very High Very High
Inflammation 65 95.36 Very High Very High Very High
agonist 44 88.28 High High
anesthesia 8 83.84 Quite High
Central nervous system 17 74.80 Quite High
Arthritis 2 57.28 Quite High
cerebral cortex 2 51.84 Quite High
Inflammatory response 12 32.08 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 93 95.36 Very High Very High Very High
Rheumatoid Arthritis 56 94.24 High High
Hepatotoxicity 4 85.76 High High
Targeted Disruption 40 80.88 Quite High
Injury 20 74.48 Quite High
Increased Venous Pressure Under Development 1 58.12 Quite High
Arthritis 2 57.28 Quite High
Asthma 1 56.84 Quite High
Disease 5 54.68 Quite High
Infection 1 43.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
animal model lacks RXR?
Negative_regulation (lacks) of RXR
1) Confidence 0.53 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.33 Pain Relevance 0.42
Furthermore, hepatocyte RXRalpha deficiency altered the gene expression profile of the glutathione S-transferase (Gst) family.
Negative_regulation (deficiency) of RXRalpha in hepatocyte
2) Confidence 0.40 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.23 Pain Relevance 1.03
In conclusion, the data presented in this study define an RXRalpha-Gst regulatory network that controls APAP-GSH conjugation.
Negative_regulation (define) of RXRalpha associated with paracetamol
3) Confidence 0.39 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.13 Pain Relevance 0.89
These mutations include RXR A416D or R421L, which specifically disrupt the formation of the RXR/TR heterodimer, and RXR A416K, which disrupts RXR/RAR and RXR/TR [58].
Negative_regulation (disrupts) of RXR
4) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Competition for RXR among the partners of RXR is also intense due to the expression of multiple NRs in the same cell and the limited availability of RXR.
Negative_regulation (availability) of RXR
5) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.13 Pain Relevance 0
For instance, the Pfahl's group has reported that simultaneous mutations of L418R, L419S, and L422Q can completely abolish RXR homo- and heterodimerization [56].
Negative_regulation (abolish) of RXR
6) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
can also reside downstream of RXR?
Negative_regulation (downstream) of RXR
7) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
In the experiments, interference of RXR
Negative_regulation (interference) of RXR
8) Confidence 0.11 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.26 Pain Relevance 0.49
These mutations include RXR A416D or R421L, which specifically disrupt the formation of the RXR/TR heterodimer, and RXR A416K, which disrupts RXR/RAR and RXR/TR [58].
Negative_regulation (disrupts) of RXR
9) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
By comparing hepatic gene expression on microarrays from germfree (GF) and conventionally-raised mice (SPF), we identified a cluster of 112 differentially expressed target genes predominantly connected to xenobiotic metabolism and pathways inhibiting RXR function.
Negative_regulation (inhibiting) of RXR
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.08

General Comments

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