INT130082

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.78
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
hepatocyte 1
epithelial cells 1
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 97.80 Very High Very High Very High
Bile 2 96.84 Very High Very High Very High
Inflammation 123 96.16 Very High Very High Very High
Paracetamol 14 95.48 Very High Very High Very High
agonist 59 87.84 High High
Inflammatory response 17 85.48 High High
cytokine 36 79.60 Quite High
Arthritis 3 54.08 Quite High
cerebral cortex 2 38.80 Quite Low
Central nervous system 20 30.80 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 149 100.00 Very High Very High Very High
Rheumatoid Arthritis 56 99.20 Very High Very High Very High
Diabetes Mellitus 26 95.52 Very High Very High Very High
Obesity 62 95.00 High High
Chronic Lymphoid Leukemia 2 94.68 High High
Metabolic Disorder 1 94.36 High High
Hepatotoxicity 2 85.76 High High
Colitis 13 82.52 Quite High
Targeted Disruption 9 80.88 Quite High
Metabolic Syndrome 3 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, hepatocyte RXRalpha deficiency altered the gene expression profile of the glutathione S-transferase (Gst) family.
Regulation (altered) of RXRalpha in hepatocyte
1) Confidence 0.42 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.23 Pain Relevance 1.03
trans-activating ability in the presence of a synthetic ligand, affecting its ability to recruit cofactors, ligands, and RXR?
Regulation (affecting) of RXR
2) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.44 Pain Relevance 0
REGULATION OF INFLAMMATORY PROCESSES BY PPAR/RXR SIGNALING IN THE SPINAL CORD
Regulation (REGULATION) of RXR associated with inflammation
3) Confidence 0.03 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.12 Pain Relevance 0.57
in epithelial cells suggests that these cells are the main target of the RXR/PPAR-?
Regulation (target) of RXR in epithelial cells
4) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.07 Pain Relevance 0.36
Nuclear receptors are part of a family of ligand-activated transcription factor such as PPARs, LXRs, RXR, involved in the regulation of many key metabolic functions both at the central and peripheral level.
Regulation (regulation) of RXR
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.28 Pain Relevance 0
The

heterodimer PPAR/RXR can bind other transcriptional coactivators or

Regulation (heterodimer) of RXR
6) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.63 Pain Relevance 0

General Comments

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