INT130083

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.81
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
plasma 8
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 89 99.98 Very High Very High Very High
Angina 20 99.48 Very High Very High Very High
aspirin 45 99.08 Very High Very High Very High
Restless leg syndrome 21 97.04 Very High Very High Very High
Inflammation 32 96.64 Very High Very High Very High
ischemia 6 88.64 High High
Inflammatory marker 3 85.96 High High
corticosteroid 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 38 100.00 Very High Very High Very High
Rheumatoid Arthritis 101 99.98 Very High Very High Very High
Cv General 3 Under Development 20 99.48 Very High Very High Very High
INFLAMMATION 35 96.64 Very High Very High Very High
Cv Unclassified Under Development 9 88.64 High High
Nicotine Addiction 4 87.92 High High
Adhesions 16 86.04 High High
Reperfusion Injury 3 77.52 Quite High
Cardiovascular Disease 21 75.04 Quite High
Atherosclerosis 29 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, only those patients with class II and III unstable AP had significantly higher circulating levels of VCAM-1 than patients with stable AP (P < 0.0001).
Positive_regulation (circulating) of Positive_regulation (levels) of VCAM-1 associated with angina
1) Confidence 0.36 Published 2005 Journal International heart journal Section Abstract Doc Link 16157948 Disease Relevance 1.43 Pain Relevance 1.33
In conclusion, in patients with intermittent claudication suffering from a greater endothelial derangement after treadmill, PLC administration provided a protective effect against deterioration of FMD and increase of sVCAM-1 induced by exercise.
Positive_regulation (increase) of Positive_regulation (induced) of sVCAM-1 associated with restless leg syndrome
2) Confidence 0.17 Published 2006 Journal Angiology Section Abstract Doc Link 16518521 Disease Relevance 0.33 Pain Relevance 0.17
The frequency and persistent time of angina pectois, dosage of nitroglycerin used, changes of electrocardiogram (ECG) were observed, and the plasma levels of endothelin (ET), nitric oxide (NO), von Willebrand factor (vWF), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were tested before and after the two-month therapeutic course.
Positive_regulation (tested) of Positive_regulation (levels) of vascular cell adhesion molecule-1 in plasma
3) Confidence 0.16 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0.16 Pain Relevance 0
Primary end point was the exercise-induced changes in brachial flow-mediated vasodilation (FMD) at day 28; secondary end points were effort-induced changes of markers of neutrophil (plasma elastase) and endothelial (soluble VCAM-1) activation.
Positive_regulation (exercise-induced) of Positive_regulation (activation) of VCAM-1 in plasma associated with increased venous pressure under development
4) Confidence 0.12 Published 2007 Journal Thromb. Haemost. Section Abstract Doc Link 17334512 Disease Relevance 1.11 Pain Relevance 0.83
Primary end point was the exercise-induced changes in brachial flow-mediated vasodilation (FMD) at day 28; secondary end points were effort-induced changes of markers of neutrophil (plasma elastase) and endothelial (soluble VCAM-1) activation.
Positive_regulation (effort-induced) of Positive_regulation (activation) of VCAM-1 in plasma associated with increased venous pressure under development
5) Confidence 0.12 Published 2007 Journal Thromb. Haemost. Section Abstract Doc Link 17334512 Disease Relevance 1.08 Pain Relevance 0.80
In conclusion, in patients with intermittent claudication suffering from a greater endothelial derangement after treadmill, PLC administration provided a protective effect against deterioration of FMD and increase of sVCAM-1 induced by exercise.
Positive_regulation (induced) of Positive_regulation (increase) of sVCAM-1 associated with restless leg syndrome
6) Confidence 0.11 Published 2006 Journal Angiology Section Abstract Doc Link 16518521 Disease Relevance 0.33 Pain Relevance 0.17
Similarly, exercise induced an increase of plasma elastase and of sVCAM-1 which were not affected by aspirin while they were suppressed by NCX 4016.
Positive_regulation (induced) of Positive_regulation (increase) of sVCAM-1 in plasma associated with aspirin
7) Confidence 0.10 Published 2007 Journal Thromb. Haemost. Section Abstract Doc Link 17334512 Disease Relevance 0.66 Pain Relevance 0.78
Compared with controls, patients with RA had significantly higher levels of, sICAM-1, MCP-1 and VWF, with a tendency also for sVCAM-1 to be higher (P = 0.059; Table 3).
Positive_regulation (had) of Positive_regulation (tendency) of sVCAM-1 associated with rheumatoid arthritis
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.70 Pain Relevance 0.23

General Comments

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