INT130096

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
neurite 2
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 98.64 Very High Very High Very High
Neurotransmitter 1 95.20 Very High Very High Very High
Neuritis 1 79.12 Quite High
palliative 1 39.20 Quite Low
Disease Link Frequency Relevance Heat
Carcinoid 8 92.64 High High
Increased Venous Pressure Under Development 4 90.20 High High
Neuroblastoma 1 88.00 High High
Neuritis 1 79.12 Quite High
Syndrome 1 72.00 Quite High
Hyperplasia 1 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to its developmental role in the GI tract, Notch1 pathway activation led to an increase in hairy enhancer of split 1 (HES-1) protein and a concomitant silencing of human Notch1/HES-1/achaete-scute homolog 1.
Positive_regulation (increase) of Positive_regulation (activation) of Notch1
1) Confidence 0.50 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.70 Pain Relevance 0
As evaluated by time lapse digital imaging, dynamic changes in neurite morphology were rapidly reversible and dependent on the activation of the Notch signaling pathway.
Positive_regulation (dependent) of Positive_regulation (activation) of Notch in neurite associated with imagery
2) Confidence 0.45 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.45 Pain Relevance 0.18

General Comments

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