INT130099

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.56
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 2
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 79.92 Quite High
palliative 3 75.68 Quite High
aspirin 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 2 99.84 Very High Very High Very High
Syndrome 4 98.96 Very High Very High Very High
Carcinoid 17 98.60 Very High Very High Very High
Cancer 34 94.28 High High
Thyroid Neoplasm 88 94.04 High High
Neuroblastoma 3 90.48 High High
Alzheimer's Dementia 4 62.16 Quite High
Small Cell Lung Cancer 1 46.80 Quite Low
Lung Cancer 1 46.56 Quite Low
Apoptosis 2 41.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, persistent activation of the Notch1 pathway in BON cells led to a notable reduction in cellular proliferation.
Negative_regulation (reduction) of Positive_regulation (activation) of Notch1 associated with hyperplasia
1) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.70 Pain Relevance 0.08
Furthermore, Notch1 activation led to a significant reduction in NE markers.
Negative_regulation (reduction) of Positive_regulation (activation) of Notch1
2) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.71 Pain Relevance 0.05
Furthermore, with Notch1 activation there was a concomitant decrease in ASCL1 in vitro, a downstream target of Notch1 signaling.
Negative_regulation (decrease) of Positive_regulation (activation) of Notch1
3) Confidence 0.29 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.09 Pain Relevance 0
Unlike wt PS1 and some of its clinical mutants, all three PS1 artificial mutants decreased cleavage of Notch S3-site, suggesting that these artificial mutations may trigger conformational changes at the substrate docking and catalytic site that cause alteration of substrate specificity and inhibition pattern.
Negative_regulation (decreased) of Positive_regulation (cleavage) of Notch in Notch
4) Confidence 0.03 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2405781 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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