INT13010

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1987
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 38
Total Number 44
Disease Relevance 14.81
Pain Relevance 8.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
melanocyte 5
neural 2
neuronal 1
brain 1
skin 1
TYR (Homo sapiens)
TYR - R402Q (1)
Pain Link Frequency Relevance Heat
gABA 124 100.00 Very High Very High Very High
Catecholamine 23 100.00 Very High Very High Very High
Serotonin 7 100.00 Very High Very High Very High
Enkephalin 14 99.80 Very High Very High Very High
melanocortin 1 receptor 41 99.60 Very High Very High Very High
Analgesic 7 99.16 Very High Very High Very High
Neurotransmitter 101 98.88 Very High Very High Very High
Dopamine 48 97.56 Very High Very High Very High
Opioid 12 97.12 Very High Very High Very High
opioid receptor 5 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Melanoma 199 100.00 Very High Very High Very High
Generalized Anxiety Disorder 57 100.00 Very High Very High Very High
Tics 16 100.00 Very High Very High Very High
Lymphatic System Cancer 10 100.00 Very High Very High Very High
Carcinoma 8 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 1 100.00 Very High Very High Very High
Death 57 99.70 Very High Very High Very High
Skin Cancer 45 98.64 Very High Very High Very High
Cirrhosis 57 97.16 Very High Very High Very High
Sprains And Strains 20 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, the Tyr-MIF-1 transporter is shared with Met-enkephalin.
Gene_expression (shared) of Tyr associated with enkephalin
1) Confidence 0.65 Published 2007 Journal Peptides Section Abstract Doc Link 17988762 Disease Relevance 0.06 Pain Relevance 0.28
The increase in intracellular cAMP ultimately stimulates the expression of enzymes important in eumelanin biosynthesis, including tyrosinase, which catalyzes the oxidation of tyrosine to dopaquinone.
Gene_expression (expression) of tyrosinase
2) Confidence 0.63 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0.16 Pain Relevance 0.36
The relationship between Na(+)/H(+) exchanger expression and tyrosinase activity in human melanocytes.
Gene_expression (expression) of tyrosinase in melanocytes
3) Confidence 0.62 Published 2004 Journal Exp. Cell Res. Section Title Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.06
Moreover, BV induced melanogenesis through increased tyrosinase expression.
Gene_expression (expression) of tyrosinase
4) Confidence 0.62 Published 2007 Journal Exp. Mol. Med. Section Abstract Doc Link 18059136 Disease Relevance 0.22 Pain Relevance 0.18
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (levels) of tyrosinase in neural
5) Confidence 0.59 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28
No change was observed in expression of gp75, neural specific octamer binding proteins, or in mRNA levels of tyrosinase, Pmel-17 and gp75 (TRP-1).
Gene_expression (expression) of tyrosinase in neural
6) Confidence 0.59 Published 1994 Journal Melanoma Res. Section Abstract Doc Link 7535606 Disease Relevance 0.41 Pain Relevance 0.28
Nine [D-Ala2]deltorphin II (DL-II:Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2) analogs having various aliphatic amino acids at positions 5 and 6 were synthesized to gain more information about the role of hydrophobic Val5,6 residues for the delta-opioid receptor selectivity.
Gene_expression (synthesized) of Tyr associated with opioid receptor
7) Confidence 0.58 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1659404 Disease Relevance 0 Pain Relevance 0.09
This hypothesis was tested through the synthesis of Tyr-L-Tic-NH2, Tyr-D-Tic-NH2, Tyr-L-Tic-Ala-NH2, Tyr-L-Tic-Ala-OH and Tyr-D-Tic-Ala-NH2.
Gene_expression (synthesis) of Tyr associated with tics
8) Confidence 0.58 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8117299 Disease Relevance 0.77 Pain Relevance 0.60
This hypothesis was tested through the synthesis of Tyr-L-Tic-NH2, Tyr-D-Tic-NH2, Tyr-L-Tic-Ala-NH2, Tyr-L-Tic-Ala-OH and Tyr-D-Tic-Ala-NH2.
Gene_expression (synthesis) of Tyr associated with tics
9) Confidence 0.58 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8117299 Disease Relevance 0.76 Pain Relevance 0.59
Dimeric analogues of the inactive enkephalin fragment Tyr-D-Ala-Gly were synthesized by cross-linking with alkanediamine at the C-terminus.
Gene_expression (synthesized) of Tyr associated with enkephalin
10) Confidence 0.58 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3039993 Disease Relevance 0 Pain Relevance 0.37
This was despite being able to show expression of tyrosinase and tyrosinase-related protein-1 markers, although at reduced levels and an ability to convert exogenous 3,4-dihydroxyphenyl-alanine (DOPA) to melanin in these strains.
Gene_expression (expression) of tyrosinase associated with sprains and strains
11) Confidence 0.47 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12753386 Disease Relevance 0.52 Pain Relevance 0.34
This was despite being able to show expression of tyrosinase and tyrosinase-related protein-1 markers, although at reduced levels and an ability to convert exogenous 3,4-dihydroxyphenyl-alanine (DOPA) to melanin in these strains.
Gene_expression (expression) of tyrosinase associated with sprains and strains
12) Confidence 0.47 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12753386 Disease Relevance 0.52 Pain Relevance 0.34
A sulfide atom and aromatic ring interaction is observed between Cys-73, Met-225 residues and Trp-1, Tyr-2, Tyr3 residues of the peptide.
Gene_expression (residues) of Tyr3
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The residues Trp, Tyr and Val are highly favored on the designed peptides.
Gene_expression (favored) of Tyr
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
A sulfide atom and aromatic ring interaction is observed between Cys-73, Met-225 residues and Trp-1, Tyr-2, Tyr3 residues of the peptide.
Gene_expression (residues) of Tyr
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
TM content, the sum of EM and PM, showed a good correlation with TM measured spectrophotometrically, and with the activity and protein levels of tyrosinase.
Gene_expression (levels) of tyrosinase
16) Confidence 0.45 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16524431 Disease Relevance 0 Pain Relevance 0.33
Here, we measured contents of eumelanin (EM) and pheomelanin (PM) in 60 primary human melanocyte cultures (51 neonatal and nine adults), and correlated some of these values with the respective activity and protein levels of tyrosinase, and the melanocortin-1 receptor (MC1R) genotype.
Gene_expression (levels) of tyrosinase in melanocyte associated with melanocortin 1 receptor
17) Confidence 0.45 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16524431 Disease Relevance 0 Pain Relevance 0.25
stacking is probable between Tyr-12 and Tyr residues.


Gene_expression (residues) of Tyr
18) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
stacking is probable between Tyr-12 and Tyr residues.


Spec (probable) Gene_expression (probable) of Tyr
19) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
Out of 36 amino acids of the peptides determined by VitAL, the 21 are Trp and Tyr residues.
Gene_expression (residues) of Tyr
20) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox