INT130111

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 3
Speculated 6
Reported most in Body
Documents 14
Total Number 22
Disease Relevance 11.01
Pain Relevance 5.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 10
epithelial cells 4
macrophages 2
smooth muscle 2
colon 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 375 100.00 Very High Very High Very High
Inflammation 295 99.36 Very High Very High Very High
cytokine 177 98.84 Very High Very High Very High
Ventral tegmentum 8 98.80 Very High Very High Very High
Osteoarthritis 225 95.28 Very High Very High Very High
rheumatoid arthritis 204 94.00 High High
Morphine 9 92.80 High High
Mechanotransduction 8 91.28 High High
Endocannabinoid 86 91.04 High High
Inflammatory stimuli 10 89.84 High High
Disease Link Frequency Relevance Heat
Down Syndrome 80 100.00 Very High Very High Very High
Adhesions 94 99.60 Very High Very High Very High
Colon Cancer 44 99.40 Very High Very High Very High
INFLAMMATION 320 99.36 Very High Very High Very High
Vibrio Infection 3 99.34 Very High Very High Very High
Disease 1016 99.32 Very High Very High Very High
Obesity 218 97.92 Very High Very High Very High
Death 76 97.76 Very High Very High Very High
Targeted Disruption 35 97.72 Very High Very High Very High
Osteoarthritis 48 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that, although ERK activation by mu- and delta-ORs is attenuated by the presence of delta-i3L, ERK activation mediated by alpha2AR remained unaffected.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (activation) of ERK
1) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.24
Effects of HU-210 on ERK1, ERK2, and p38 MAPK activation in fibroblast-like cells
Spec (like) Regulation (Effects) of Positive_regulation (activation) of p38 in fibroblast
2) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.31 Pain Relevance 0.79
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Regulation (dependent) of Positive_regulation (activation) of ERK in fibroblasts associated with disease and bradykinin
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.97 Pain Relevance 0.48
Effects of HU-210 on ERK1, ERK2, and p38 MAPK activation in fibroblast-like cells
Spec (like) Regulation (Effects) of Positive_regulation (activation) of p38 in fibroblast
4) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.31 Pain Relevance 0.79
Its presence and function in myometrial smooth muscle have not been previously studied, but it has been shown to regulate both ERK activation and contractility in vascular smooth muscle [8].
Regulation (regulate) of Positive_regulation (activation) of ERK in smooth muscle
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.22 Pain Relevance 0
In the current study we used an in vitro experimental stretch model to investigate the effect of stretch on ERK, CaD phosphorylation and activation of focal adhesion signaling.
Spec (investigate) Regulation (effect) of Positive_regulation (activation) of ERK associated with adhesions
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.55 Pain Relevance 0.08
PS-2 (N141I) AD fibroblasts treated with 10 nM Compound E also displayed no effect on BK-induced ERK activation (data not shown).
Neg (no) Regulation (effect) of Positive_regulation (activation) of ERK in fibroblasts associated with disease and bradykinin
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.75 Pain Relevance 0.37
Thus the decreased responsiveness of ERK activation by 250 nM BK is specifically associated with PS-1 mutant AD.
Regulation (responsiveness) of Positive_regulation (activation) of ERK associated with disease and bradykinin
8) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.29 Pain Relevance 0.38
Compound E had neither an effect on BK-induced ERK activation in Trisomy 21 and control fibroblasts, nor on BK-stimulated ERK in PS-2 (N141I) AD fibroblasts.
Neg (neither) Regulation (effect) of Positive_regulation (activation) of ERK in fibroblasts associated with down syndrome, disease and bradykinin
9) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.50 Pain Relevance 0.33
We hypothesize that this may reflect differential PS-1 versus PS-2 roles in the signal transduction cascades proceeding onward to ERK activation.
Regulation (roles) of Positive_regulation (activation) of ERK
10) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.64 Pain Relevance 0.21
Furthermore, as the mitogen-activated protein kinase kinase 1 (MAPKK1) was increased significantly in the stages of establishment and reinstatement, we confirmed the change of activated extracellular signal-regulated kinase (ERK) by Western blotting in VTA tissue and cultured cell.
Regulation (change) of Positive_regulation (activated) of extracellular signal-regulated kinase associated with ventral tegmentum
11) Confidence 0.17 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20091775 Disease Relevance 0.13 Pain Relevance 1.24
regulated an MAP3K involved in ERK1/2 activation selectively by inflammatory cytokines.
Regulation (involved) of Positive_regulation (activation) of ERK1/2 associated with inflammation and cytokine
12) Confidence 0.15 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.75 Pain Relevance 0.23
Although data on the role and mode of activation of GADD45 proteins in T cells are still controversial, the regulation of the expression levels of GADD45 proteins constitutes an indirect additional mechanism to control the intensity and duration of p38 MAPK activation.
Regulation (control) of Positive_regulation (activation) of p38 MAPK in T cells
13) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.06 Pain Relevance 0.04
In order to verify that EGFR signaling was intact in our cells, the effects of EGF treatment on the expression and activation of EGFR and ERK1/2 in HT29 human colon cancer cells was examined.
Spec (examined) Regulation (effects) of Positive_regulation (activation) of ERK1/2 in colon associated with colon cancer
14) Confidence 0.12 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.26 Pain Relevance 0.04
may be responsible for this upregulation via a mechanism that seems to involve the activation of the JNK and p38 MAPK and NF-?
Spec (seems) Regulation (involve) of Positive_regulation (activation) of p38 MAPK
15) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.61 Pain Relevance 0.28
TTSS1 of V. parahaemolyticus is responsible for activation of JNK, p38 and ERK in epithelial cells
Regulation (responsible) of Positive_regulation (activation) of p38 in epithelial cells
16) Confidence 0.10 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0 Pain Relevance 0
After H2O2 treatment, the cells were analyzed by immunoblotting (IB) to determine the effect of the above inhibitors on activation of ERK (A), PKB (B), and APP processing (C).
Spec (determine) Regulation (effect) of Positive_regulation (activation) of ERK
17) Confidence 0.08 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.07 Pain Relevance 0
TTSS1 of V. parahaemolyticus is responsible for activation of JNK, p38 and ERK in epithelial cells
Regulation (responsible) of Positive_regulation (activation) of ERK in epithelial cells
18) Confidence 0.08 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0 Pain Relevance 0
The CtxB cholera toxin from Vibrio cholerae down-regulates p38 and JNK activation in macrophages leading to suppression of production of TNF?
Regulation (regulates) of Positive_regulation (activation) of p38 in macrophages associated with vibrio infection
19) Confidence 0.08 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.67 Pain Relevance 0.13
The activation of both p38 and ERK has been shown to lead to the release of TNF?
Regulation (lead) of Positive_regulation (activation) of ERK
20) Confidence 0.07 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.24 Pain Relevance 0.15

General Comments

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