INT130112

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DLL3)
Anatomy Link Frequency
embryonic kidney 1
DLL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 98.32 Very High Very High Very High
antagonist 5 97.88 Very High Very High Very High
Opioid 10 96.48 Very High Very High Very High
opioid receptor 20 96.08 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, delta-i3L expression resulted in inhibition of delta-, mu-OR-, and alpha2AR-receptor-mediated cAMP accumulation, whereas the cAMP response produced by activation of the beta2-adrenergic receptor was unaffected, suggesting that the inhibitory effects of delta-i3L expression were selective for Gi/Go proteins.
Gene_expression (expression) of delta-i3L
1) Confidence 0.25 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.43
Finally, we also examined the effects of delta-i3L expression on the regulation of the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase pathway.
Gene_expression (expression) of delta-i3L
2) Confidence 0.25 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.33
Moreover, although delta-i3L expression also attenuated drastically phospholipase C accumulation and Ca2+ release following mu- and delta-OR stimulation, it failed to inhibit carbachol-mediated stimulation of inositol phosphate accumulation in M1-muscarinic receptor-expressing human embryonic kidney 293 cells.
Gene_expression (expression) of delta-i3L in embryonic kidney
3) Confidence 0.25 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.38
In delta-i3L-expressing cells, the peptide blocked high-affinity agonist binding to both the delta- and the mu-opioid (delta-OR and mu-OR) and attenuated opioid and alpha2-adrenergic receptor (alpha2AR)-dependent [35S]guanosine-5'-O-(3-thio)triphosphate binding.
Gene_expression (expressing) of delta-i3L-expressing associated with agonist and opioid
4) Confidence 0.19 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.46
Furthermore, delta-i3L expression resulted in inhibition of delta-, mu-OR-, and alpha2AR-receptor-mediated cAMP accumulation, whereas the cAMP response produced by activation of the beta2-adrenergic receptor was unaffected, suggesting that the inhibitory effects of delta-i3L expression were selective for Gi/Go proteins.
Gene_expression (expression) of delta-i3L
5) Confidence 0.17 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.39

General Comments

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