INT130125

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.87
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 1
vessels 1
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 90.36 High High
Sciatic nerve 1 75.00 Quite High
Inflammation 20 68.40 Quite High
Inflammatory mediators 6 50.48 Quite High
Central nervous system 9 37.48 Quite Low
ischemia 7 32.40 Quite Low
alcohol 4 12.24 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 11 99.96 Very High Very High Very High
Neuropathic Pain 1 90.36 High High
Pressure And Volume Under Development 4 80.40 Quite High
Adult Respiratory Distress Syndrome 28 79.04 Quite High
Sepsis 40 69.96 Quite High
INFLAMMATION 28 68.40 Quite High
Urological Neuroanatomy 2 64.00 Quite High
Death 10 42.52 Quite Low
Neurodegenerative Disease 3 36.08 Quite Low
Brain Hemorrhage 2 33.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven days after injury, immunoreactivities for occludin and ZO-1 were observed, although there was no connexin 43 detected.
Regulation (immunoreactivities) of occludin associated with injury
1) Confidence 0.44 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 16162451 Disease Relevance 0.37 Pain Relevance 0.13
Occludin distribution in sham was not affected by treatment.
Neg (not) Regulation (affected) of Occludin
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.16 Pain Relevance 0
Interestingly, ERK inhibition did not affect occludin concentration, in either septic or control monolayers.
Neg (not) Regulation (affect) of occludin
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.21 Pain Relevance 0.03
Here we show that the protein levels of occludin and ZO-1 are not altered, but instead their interaction is considerably reduced in the sonicated brain areas, suggesting that the decrease in immunogold signals may be the consequence of the redistribution of tight junction proteins.
Regulation (altered) of occludin in brain
4) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
The data indicate that the proteins claudin-5 and occludin are down-regulated in the vessels of treated animals, suggesting impairment of the BBB.
Regulation (regulated) of occludin in vessels
5) Confidence 0.05 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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