INT130126

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
brain 1
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 90.36 High High
Sciatic nerve 1 75.00 Quite High
Central nervous system 4 36.96 Quite Low
ischemia 6 32.40 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 7 99.96 Very High Very High Very High
Neuropathic Pain 1 90.36 High High
Pressure And Volume Under Development 2 84.16 Quite High
Adult Respiratory Distress Syndrome 14 82.80 Quite High
Brain Hemorrhage 2 33.60 Quite Low
Sepsis 20 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hypoxia 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven days after injury, immunoreactivities for occludin and ZO-1 were observed, although there was no connexin 43 detected.
Regulation (immunoreactivities) of ZO-1 associated with injury
1) Confidence 0.43 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 16162451 Disease Relevance 0.37 Pain Relevance 0.13
No changes in claudin 18 or ZO-1 were observed in sham or 2CLP following treatment with U0126.


Neg (No) Regulation (changes) of ZO-1
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.17 Pain Relevance 0
Here we show that the protein levels of occludin and ZO-1 are not altered, but instead their interaction is considerably reduced in the sonicated brain areas, suggesting that the decrease in immunogold signals may be the consequence of the redistribution of tight junction proteins.
Regulation (altered) of ZO-1 in brain
3) Confidence 0.18 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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