INT130128

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0.98
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ocln, Tjp1) cytoplasm (Ocln, Tjp1) cytosol (Ocln)
Golgi apparatus (Tjp1) nucleus (Tjp1)
Anatomy Link Frequency
brain 1
Ocln (Rattus norvegicus)
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 90.36 High High
Sciatic nerve 1 75.00 Quite High
ischemia 40 73.12 Quite High
Intracerebroventricular 8 58.40 Quite High
anesthesia 8 45.52 Quite Low
ketamine 8 42.40 Quite Low
cva 8 40.24 Quite Low
Central nervous system 32 27.60 Quite Low
imagery 16 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 3 99.96 Very High Very High Very High
Neuropathic Pain 1 90.36 High High
Osteoarthritis 16 82.08 Quite High
Apoptosis 8 78.80 Quite High
Brain Hemorrhage 16 74.32 Quite High
Stroke 8 57.80 Quite High
Targeted Disruption 8 54.32 Quite High
Hypoxia 24 45.08 Quite Low
Brain Injury 24 41.00 Quite Low
Cv General 4 Under Development 16 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Seven days after injury, immunoreactivities for occludin and ZO-1 were observed, although there was no connexin 43 detected.
occludin Binding (immunoreactivities) of ZO-1 associated with injury
1) Confidence 0.38 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 16162451 Disease Relevance 0.37 Pain Relevance 0.13
The intracellular portion of occludin interacts with the intracellular scaffolding proteins ZO-1 and ZO-2, providing a link to the cytoskeletal protein actin, which establishes the tight junction structure.
occludin Binding (interacts) of ZO-1
2) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Diminished interaction of Zo-1 with occludin in response to ultrasound
occludin Binding (interaction) of Zo-1
3) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
The interaction of occludin and ZO-1 is required for proper functioning of the tight junctions and is also subject to tight regulation by several mechanisms [1,35].
occludin Binding (interaction) of ZO-1
4) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.05 Pain Relevance 0.03
It has been shown that the post-translational modifications play an essential role in controlling the interaction of occludin and ZO-1.
occludin Binding (interaction) of ZO-1
5) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04
In the following study we show that the application of focused ultrasound in combination with ultrasound contrast agent disrupts the BBB integrity, and that this disruption is associated with reduced interaction of the tight junction protein occludin with ZO-1.
occludin Binding (interaction) of ZO-1
6) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.14 Pain Relevance 0
Given that the phosphorylation of the proteins is an immediate event and the disruption of the BBB also occurs shortly after sonication, it is plausible that the ultrasound-mediated diminished interaction of occludin and ZO-1 is due to alteration in phosphorylation level of tight junction proteins.
occludin Binding (interaction) of ZO-1
7) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.07 Pain Relevance 0.04
Our data provides evidence that focused ultrasound in the presence of circulating ultrasound contrast agents (microbubbles) disrupts the interaction of tight junction proteins (occludin and ZO-1), thus affecting the integrity of the BBB.
occludin Binding (interaction) of ZO-1
8) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.27 Pain Relevance 0.06
However, using immunoprecipitation analysis we show that the interaction of occludin and ZO-1 is reduced in the brain regions treated with ultrasound (Figure 3B).


occludin Binding (interaction) of ZO-1 in brain
9) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0

General Comments

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