INT13013

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.30
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adcy5) plasma membrane (Adcy5)
Anatomy Link Frequency
MDCK 2
striatum 1
Adcy5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 99.78 Very High Very High Very High
Enkephalin 3 99.50 Very High Very High Very High
Analgesic 1 99.50 Very High Very High Very High
Clonidine 2 91.28 High High
opiate 1 87.84 High High
addiction 1 87.56 High High
Dopamine 119 80.68 Quite High
opioid receptor 1 79.60 Quite High
agonist 5 74.24 Quite High
Morphine 1 73.92 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 87.84 High High
Cyst 4 75.00 Quite High
Bordatella Infection 1 63.12 Quite High
Polycystic Kidney Disease 4 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binds to and activates adenylate cyclase type V (AC5) in the striatum [70,71,87], which produces cyclic AMP (cAMP).
Positive_regulation (activates) of adenylate cyclase type V in striatum
1) Confidence 0.67 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.24
Chronic opioid treatment induces adenylyl cyclase V superactivation.
Positive_regulation (induces) of cyclase V associated with analgesic and opioid
2) Confidence 0.04 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8702909 Disease Relevance 0.15 Pain Relevance 0.99
It is suggested that AVP stimulates fluid secretion of MDCK epithelial monolayers by activating V2 receptor-mediated adenylate cyclase.
Positive_regulation (activating) of V2 receptor-mediated adenylate cyclase in MDCK
3) Confidence 0.00 Published 1991 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 1659462 Disease Relevance 0.07 Pain Relevance 0.13
It is suggested that AVP stimulates fluid secretion of MDCK epithelial monolayers by activating V2 receptor-mediated adenylate cyclase.
Positive_regulation (activating) of V2 receptor-mediated adenylate cyclase in MDCK
4) Confidence 0.00 Published 1991 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 1659462 Disease Relevance 0.07 Pain Relevance 0.13

General Comments

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