INT130142

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S100A10)
Anatomy Link Frequency
fibroblast 1
A549 1
S100A10 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 7 96.96 Very High Very High Very High
Inflammation 3 76.68 Quite High
cINOD 1 69.12 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 127 99.40 Very High Very High Very High
Adenocarcinoma 1 86.48 High High
Necrosis 1 84.40 Quite High
Cancer 3 84.04 Quite High
INFLAMMATION 5 76.68 Quite High
Disease 1 71.00 Quite High
Malignant Neoplastic Disease 2 65.96 Quite High
Wound Healing 5 28.64 Quite Low
Hypoxia 21 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, increase in S100A10 levels in the adhesion fibroblasts may deplete intracellular levels of archidonic acid and Prostaglandin E2 (PGE2) that are known to inhibit cell proliferation, collagen I synthesis, contraction of ECM and fibroblast migration [25].
Positive_regulation (increase) of S100A10 in fibroblast associated with adhesions
1) Confidence 0.41 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.72 Pain Relevance 0
Flow cytometric analysis at a single-cell level in A549 cells indicated that TNF-alpha treatment caused early induction of p-Ser10 at 15 min, which was inhibited significantly by pretreatment with 10(-5) M Dex.
Positive_regulation (induction) of p-Ser10 in A549 associated with dexamethasone
2) Confidence 0.07 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16165091 Disease Relevance 0.61 Pain Relevance 0.47

General Comments

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