INT130144

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.38
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HIST1H3I (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 14 99.80 Very High Very High Very High
Inflammation 8 99.32 Very High Very High Very High
cINOD 2 97.84 Very High Very High Very High
Kinase C 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 99.68 Very High Very High Very High
INFLAMMATION 10 99.32 Very High Very High Very High
Cancer 40 83.80 Quite High
Necrosis 3 81.96 Quite High
Adenocarcinoma 5 80.12 Quite High
Toxicity 18 50.00 Quite Low
Sarcoma 1 44.60 Quite Low
Squamous Cell Carcinoma 4 37.96 Quite Low
Skin Cancer 4 36.96 Quite Low
Bladder Cancer 1 16.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone inhibits phosphorylation of histone H3 at serine 10.
Phosphorylation (phosphorylation) of histone H3 associated with dexamethasone
1) Confidence 0.29 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 16165091 Disease Relevance 0.67 Pain Relevance 0.47
While phosphorylation of histone H3 at serine 10 (p-Ser10) is one of the histone modifications related to transcription of some inflammation-related genes, the effect of glucocorticoids on p-Ser10 is not established.
Phosphorylation (phosphorylation) of histone H3 associated with inflammation
2) Confidence 0.29 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16165091 Disease Relevance 0.62 Pain Relevance 0.34
We have shown that the abrogating effect involves early restoration of cyclin B1 and p34 cdc-2 levels in the mitosis promoting factor to pre-irradiation levels [43,44] and also gives rise to a 3–5 fold increase of Histone H3 phosphorylation [3] which is diagnostic of mitotic progression [18].
Phosphorylation (phosphorylation) of Histone H3
3) Confidence 0.01 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.08 Pain Relevance 0
Effects of VPA on the degree of Erk1/2 phosphorylation and histone H3 acetylation
Phosphorylation (phosphorylation) of histone H3
4) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0

General Comments

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